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Article
Successful peripheral blood stem cell mobilization using pegfilgrastim in allogeneic stem cell transplantation
Pegfilgrastim is produced by binding a 20,000-dalton polyethylene glycol molecule to granulocyte colony-stimulating factor (G-CSF), increasing the mass of the compound, and resulting in a longer-lasting form o...
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Article
Open AccessRadionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer
Most cancer patients succumb to disseminated disease because conventional systemic therapies lack spatiotemporal control of their toxic effects in vivo, particularly in a complicated milieu such as bone marrow...
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Article
Open AccessAblation of VLA4 in multiple myeloma cells redirects tumor spread and prolongs survival
Multiple myeloma (MM) is a cancer of bone marrow (BM) plasma cells, which is increasingly treatable but still incurable. In 90% of MM patients, severe osteolysis results from pathological interactions between ...