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Article
Rapid Analysis of the Quality of Amoxicillin and Clavulanate Potassium Tablets Using Diffuse Reflectance Near-Infrared Spectroscopy
The cycle-closed dimer of amoxicillin influences its critical quality and is an important impurity in amoxicillin and clavulanate potassium tablets. The quality of the tablets could be rapidly evaluated using ...
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Article
Establishment and Optimization of an HPTLC Method for the Analysis of Gatifloxacin and Related Substances by Design of Experiment
The objective of this study was to establish and optimize high-performance thin-layer chromatography (HPTLC) analysis of gatifloxacin and related substances by the method of design of experiment (DOE). First, ...
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Article
A Training Set Selection Strategy for a Universal Near-Infrared Quantitative Model
The purpose of this article is to propose an empirical solution to the problem of how many clusters of complex samples should be selected to construct the training set for a universal near infrared quantitativ...
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Article
Compilation of an ESI-MS Library of β-Lactam Antibiotics for Rapid Identification of Drugs
β-Lactam antibiotics are among the most frequently used in clinical therapy. Thirty-three cephalosporin and eleven penicillin antibiotics frequently used in China have been used to create an ESI-MS library. A ...
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Article
Comparison of Three RP-HPLC Methods for Analysis of Cefpodoxime Proxetil and Related Substances
A comparison of testing methods for analysis of cefpodoxime proxetil and its related substances was performed to determine which available analytical method was most appropriate for quality control. Three RP-H...
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Article
Analysis of Spectinomycin by HPLC with Evaporative Light-Scattering Detection
A high-performance liquid chromatographic method with evaporative light-scattering detection (ELSD) has been developed for analysis of spectinomycin and related impurities. Separation of spectinomycin from str...
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Article
Establishment of a Knowledge Base for Prescreening Residual Solvents in Pharmaceuticals
A knowledge base for determining residual solvents in pharmaceuticals has been established using static headspace gas chromatography (HS-GC). Fifty-one solvents which belong to four different classes according...
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Article
RP-HPLC determination of midecamycin and related impurities
A method has been developed for separation and quantitation of midecamycin A1 and related impurities by high-performance liquid chromatography with evaporative light-scattering detection (ELSD). Chromatographic c...