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The effect of methotrexate versus other disease-modifying anti-rheumatic drugs on serum drug levels and clinical response in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors

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  1. Article

    Open Access

    Harnessing ChatGPT and GPT-4 for evaluating the rheumatology questions of the Spanish access exam to specialized medical training

    The emergence of large language models (LLM) with remarkable performance such as ChatGPT and GPT-4, has led to an unprecedented uptake in the population. One of their most promising and studied applications co...

    Alfredo Madrid-García, Zulema Rosales-Rosado, Dalifer Freites-Nuñez in Scientific Reports (2023)

  2. Article

    Open Access

    Immune response after SARS-CoV-2 vaccination in patients with inflammatory immune-mediated diseases receiving immunosuppressive treatment

    Real world data on the response to the SARS-CoV-2 vaccine in patients with immunomediated diseases (IMIDs) treated with immunesuppressants is of great interest because vaccine response may be impaired. The mai...

    Chamaida Plasencia-Rodríguez, Ana Martínez-Feito in Allergy, Asthma & Clinical Immunology (2023)

  3. Article

    Open Access

    Co** with rheumatic stressors (CORS) questionnaire: Spanish translation and cross-cultural adaptation

    Rheumatic and Musculoskeletal Diseases (RMDs) substantially impact the lives of patients, with complex associations between disease severity and self-perceived health status. In this regard, the Co** with Rh...

    Diego Benavent, Andrea Jochems in Journal of Patient-Reported Outcomes (2023)

  4. Article

    Open Access

    BAFF predicts immunogenicity in older patients with rheumatoid arthritis treated with TNF inhibitors

    Immunogenicity related to treatment with TNF inhibitors (TNFi) is one of the causes for the decreased attainment of clinical response in patients with rheumatoid arthritis (RA). The B-cell activating factor (B...

    Borja Hernández-Breijo, Victoria Navarro-Compán in Scientific Reports (2021)

  5. Article

    Open Access

    Vaspin in atherosclerotic disease and cardiovascular risk in axial spondyloarthritis: a genetic and serological study

    Vaspin is a novel anti-inflammatory adipokine associated with cardiovascular (CV) disease and inflammation in chronic inflammatory conditions different from axial spondyloarthritis (axSpA). Given the high inci...

    Javier Rueda-Gotor, Raquel López-Mejías in Arthritis Research & Therapy (2021)

  6. Article

    Open Access

    Infliximab concentrations in two non-switching cohorts of patients with inflammatory bowel disease: originator vs. biosimilar

    Biosimilars are replacing originator compounds due to their similar effectiveness, safety and pharmacokinetics. Our objective was to compare the differences in pharmacokinetics and clinical outcomes between th...

    Ana Martínez-Feito, Luz Yadira Bravo-Gallego, Borja Hernández-Breijo in Scientific Reports (2020)

  7. Article

    Open Access

    Association between concomitant csDMARDs and clinical response to TNF inhibitors in overweight patients with axial spondyloarthritis

    The aim of our study was to investigate the influence of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) and body mass index (BMI) on circulating drug levels and clinical response to t...

    Borja Hernández-Breijo, Chamaida Plasencia-Rodríguez in Arthritis Research & Therapy (2019)