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15 Result(s)

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  1. No Access

    Article

    Fine-map** of 150 breast cancer risk regions identifies 191 likely target genes

    Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining asso...

    Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R. Barnes… in Nature Genetics (2020)

  2. No Access

    Article

    Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

    Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants an...

    Roger L Milne, Karoline B Kuchenbaecker, Kyriaki Michailidou… in Nature Genetics (2017)

  3. No Access

    Article

    Five endometrial cancer risk loci identified through genome-wide association analysis

    Amanda Spurdle, Ian Tomlinson, Douglas Easton and colleagues conduct a GWAS meta-analysis and identify five new risk loci for endometrial cancer. Functional studies show that one risk-associated SNP is located...

    Timothy H T Cheng, Deborah J Thompson, Tracy A O'Mara, Jodie N Painter… in Nature Genetics (2016)

  4. No Access

    Article

    Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170

    Alison Dunning, Stacey Edwards and colleagues analyze 3,872 common variants across the ESR1 locus in 118,816 women. They find five independent variants within regulatory regions that associate with different brea...

    Alison M Dunning, Kyriaki Michailidou, Karoline B Kuchenbaecker… in Nature Genetics (2016)

  5. No Access

    Article

    Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

    Doug Easton and colleagues report the results of a large-scale genome-wide association study of breast cancer. They discover 15 new susceptibility loci and highlight likely target genes in several of the newly...

    Kyriaki Michailidou, Jonathan Beesley, Sara Lindstrom, Sander Canisius… in Nature Genetics (2015)

  6. Article

    Open Access

    Candidate locus analysis of the TERT–CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk

    Several studies have reported associations between multiple cancer types and single-nucleotide polymorphisms (SNPs) on chromosome 5p15, which harbours TERT and CLPTM1L, but no such association has been reported w...

    Luis G. Carvajal-Carmona, Tracy A. O’Mara, Jodie N. Painter… in Human Genetics (2015)

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  7. No Access

    Article

    Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning and colleagues report common variants at the TERT-CLPTM1L locus associated with mean telomere length measured in whole blood. They also identify associations ...

    Stig E Bojesen, Karen A Pooley, Sharon E Johnatty, Jonathan Beesley… in Nature Genetics (2013)

  8. No Access

    Article

    Genome-wide association study identifies a common variant associated with risk of endometrial cancer

    Amanda Spurdle and colleagues report results of a genome-wide association study of endometrial cancer. They identify a risk variant near HNF1B that has previously been associated with increased risk of prostate c...

    Amanda B Spurdle, Deborah J Thompson, Shahana Ahmed, Kaltin Ferguson… in Nature Genetics (2011)

  9. No Access

    Article

    Genome-wide association study identifies five new breast cancer susceptibility loci

    Douglas Easton and colleagues report a genome-wide association study for breast cancer, identifying five new susceptibility loci.

    Clare Turnbull, Shahana Ahmed, Jonathan Morrison, David Pernet… in Nature Genetics (2010)

  10. No Access

    Article

    Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

    Douglas Easton and colleagues report results of a large multistage genome-wide association study of breast cancer. The study identifies two new breast cancer risk loci on chromosomes 3p24 and 17q23.2.

    Shahana Ahmed, Gilles Thomas, Maya Ghoussaini, Catherine S Healey… in Nature Genetics (2009)

  11. Article

    Open Access

    Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk

    Certain rare, familial mutations in the ATM, BRCA1, BRCA2, CHEK2 or TP53 genes increase susceptibility to breast cancer but it has not, until now, been clear whether common polymorphic variants in the same genes ...

    Caroline Baynes, Catherine S Healey, Karen A Pooley… in Breast Cancer Research (2007)

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  12. Article

    Red clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial [ISRCTN42940165]

    Isoflavones are hypothesized to protect against breast cancer, but it is not clear whether they act as oestrogens or anti-oestrogens in breast tissue. Our aim was to determine the effects of taking a red clove...

    Charlotte Atkinson, Ruth ML Warren, Evis Sala, Mitch Dowsett… in Breast Cancer Research (2004)

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  13. No Access

    Article

    A common variant in BRCA2 is associated with both breast cancer risk and prenatal viability

    Inherited mutations in the gene BRCA2 predispose carriers to early onset breast cancer, but such mutations account for fewer than 2% of all cases in East Anglia. It is likely that low penetrance alleles explain t...

    Catherine S. Healey, Alison M. Dunning, M. Dawn Teare, Diana Chase… in Nature Genetics (2000)

  14. No Access

    Article

    A polymorphic stop codon in BRCA2

    Sylvie Mazoyer, Alison M. Dunning, Olga Serova, Joanna Dearden… in Nature Genetics (1996)

  15. No Access

    Article

    Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC

    We have analysed 118 families with inherited medullary thyroid carcinoma (MTC) for mutations of the RET proto–oncogene. These included cases of multiple endocrine neoplasia types 2A (MEN 2A) and 2B (MEN 2B) and f...

    Lois M. Mulligan, Charis Eng, Catherine S. Healey, David Clayton… in Nature Genetics (1994)