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Article
Open AccessASP-2/Trans-sialidase chimeric protein induces robust protective immunity in experimental models of Chagas’ disease
Immunization with the Amastigote Surface Protein-2 (ASP-2) and Trans-sialidase (TS) antigens either in the form of recombinant protein, encoded in plasmids or human adenovirus 5 (hAd5) confers robust protection a...
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Article
γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis
Activated Vγ9Vδ2 (γδ2) T lymphocytes that sense parasite-produced phosphoantigens are expanded in Plasmodium falciparum–infected patients. Although previous studies suggested that γδ2 T cells help control erythro...
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Article
Cytotoxic CD8+ T cells recognize and kill Plasmodium vivax–infected reticulocytes
Plasmodium vivax causes approximately 100 million clinical malaria cases yearly1,2. The basis of protective immunity is poorly understood and thought to be mediated by antibodies3,4. Cytotoxic CD8+ T cells protec...