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  1. Article

    Open Access

    Mining multi-item drug adverse effect associations in spontaneous reporting systems

    Multi-item adverse drug event (ADE) associations are associations relating multiple drugs to possibly multiple adverse events. The current standard in pharmacovigilance is bivariate association analysis, where...

    Rave Harpaz, Herbert S Chase, Carol Friedman in BMC Bioinformatics (2010)

  2. Article

    Open Access

    Characterizing environmental and phenotypic associations using information theory and electronic health records

    The availability of up-to-date, executable, evidence-based medical knowledge is essential for many clinical applications, such as pharmacovigilance, but executable knowledge is costly to obtain and update. Aut...

    **aoyan Wang, George Hripcsak, Carol Friedman in BMC Bioinformatics (2009)

  3. Article

    Open Access

    PhenoGO: an integrated resource for the multiscale mining of clinical and biological data

    The evolving complexity of genome-scale experiments has increasingly centralized the role of a highly computable, accurate, and comprehensive resource spanning multiple biological scales and viewpoints. To pro...

    Lee T Sam, Eneida A Mendonça, Jianrong Li, Judith Blake in BMC Bioinformatics (2009)

  4. Article

    Open Access

    Using contextual and lexical features to restructure and validate the classification of biomedical concepts

    Biomedical ontologies are critical for integration of data from diverse sources and for use by knowledge-based biomedical applications, especially natural language processing as well as associated mining and r...

    Jung-Wei Fan, Hua Xu, Carol Friedman in BMC Bioinformatics (2007)

  5. Article

    Open Access

    Machine learning and word sense disambiguation in the biomedical domain: design and evaluation issues

    Word sense disambiguation (WSD) is critical in the biomedical domain for improving the precision of natural language processing (NLP), text mining, and information retrieval systems because ambiguous words neg...

    Hua Xu, Marianthi Markatou, Rositsa Dimova, Hongfang Liu in BMC Bioinformatics (2006)