5 Result(s)
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Article
Open AccessEndogenous murine leukemia retroviral variation across wild European and inbred strains of house mouse
Endogenous murine leukemia retroviruses (MLVs) are high copy number proviral elements difficult to comprehensively characterize using standard low throughput sequencing approaches. However, high throughput app...
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Article
Open AccessWhole genome sequencing and methylome analysis of the wild guinea pig
DNA methylation is a heritable mechanism that acts in response to environmental changes, lifestyle and diseases by influencing gene expression in eukaryotes. Epigenetic studies of wild organisms are mandatory ...
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Article
Open AccessMHC genoty** of non-model organisms using next-generation sequencing: a new methodology to deal with artefacts and allelic dropout
The Major Histocompatibility Complex (MHC) is the most important genetic marker to study patterns of adaptive genetic variation determining pathogen resistance and associated life history decisions. It is used...
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Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity
Mark Achtman and colleagues report the whole-genome sequencing of 11 Yersinia pestis isolates, the causative agent of the plague. Their phylogeographic analysis on a larger dataset of Y. pestis global isolates su...
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Article
High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi
Isolates of Salmonella enterica serovar Typhi (Typhi), a human-restricted bacterial pathogen that causes typhoid, show limited genetic variation. Kathryn Holt and colleagues now compare whole-genome sequences of ...
