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  1. Article

    Open Access

    Selective suppression of the JNK-MMP2/9 signal pathway by tetramethylpyrazine attenuates neuropathic pain in rats

    Activated astrocytes release matrix metalloproteinase-2/9 (MMP-2/9) to induce central sensitization and maintain neuropathic pain. However, the mechanisms involved in the activation of MMP-2/9 on astrocytes du...

    Lai Jiang, Cai-Long Pan, Chao-Yu Wang, Bing-Qian Liu… in Journal of Neuroinflammation (2017)

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  2. Article

    Open Access

    Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling

    Alzheimer’s disease (AD) is a major clinical problem, but there is a distinct lack of effective therapeutic drugs for this disease. We investigated the potential therapeutic effects of zerumbone, a subtropical...

    Lei Li, **ang-Hui Wu, **ao-**g Zhao, Lu Xu, Cai-Long Pan… in Journal of Neuroinflammation (2020)

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  3. No Access

    Article

    Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy

    Neuronal loss is a primary factor in determining the outcome of ischemic stroke. Oridonin (Ori), a natural diterpenoid compound extracted from the Chinese herb Rabdosia rubescens, has been shown to exert anti-inf...

    Lei Li, **g-**g Song, Meng-xue Zhang, Hui-wen Zhang… in Acta Pharmacologica Sinica (2023)