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Open AccessAMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-...
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Article
Can the greening of the tax system improve enterprises’ ESG performance? Evidence from China
Can the greening of the tax system truly drive high-quality development of enterprises? ESG, as an investment concept and evaluation criterion focusing on corporate sustainable development, is an essential too...
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Metal–ligand cross-link strategy engineered iron-doped dopamine-based superstructure as peroxidase-like nanozymes for detection of glucose
Nanozymes are nanomaterials with mimetic enzyme properties and the related research has attracted much attention. It is of great value to develop methods to construct nanozymes and to study their application i...
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Remarkable electrochemical performance of holey MXene/graphene hydrogel-based supercapacitor operated at − 60 °C in sulfuric acid aqueous electrolyte
The ability to store and deliver electricity quickly at low temperatures is crucial for exploring unknown spaces under harsh conditions. In this work, we present a supercapacitor with excellent high power dens...
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Open AccessFerroptosis-related lncRNA NRAV affects the prognosis of hepatocellular carcinoma via the miR-375-3P/SLC7A11 axis
Ferroptosis has important value in cancer treatment. It is significant to explore the new ferroptosis-related lncRNAs prediction model in Hepatocellular carcinoma (HCC) and the potential molecular mechanism of...
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Open AccessQTL map** for the flag leaf-related traits using RILs derived from Trititrigia germplasm line SN304 and wheat cultivar Yannong15 in multiple environments
Develo** and enriching genetic resources plays important role in the crop improvement. The flag leaf affects plant architecture and contributes to the grain yield of wheat (Triticum aestivum L.). The genetic im...
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Reduced PATL2 Impairs the Proliferation of Ovarian Granulosa Cells by Decreasing ADM2 Expression in Patients with PCOS
It is recognized that PCOS patients are often accompanied with aberrant follicular development, which is an important factor leading to infertility in patients. However, the relevant regulatory mechanisms of a...
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Open AccessHygrothermal stress increases malignant arrhythmias susceptibility by inhibiting the LKB1-AMPK-Cx43 pathway
High mortality due to hygrothermal stress during heat waves is mostly linked to cardiovascular malfunction, the most serious of which are malignant arrhythmias. However, the mechanism associated with hygrother...
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New instability model leading the wrinkling at the positive-curvature arc part during the tube hydro-forging process
The tube hydroforging process (THFG) is an advanced technology for manufacturing tubular components with complex cross-sections. The positive-curvature arc is one of the most fundamental and difficult-to-form ...
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Open AccessAuthor Correction: AGEs Induced Autophagy Impairs Cutaneous Wound Healing via Stimulating Macrophage Polarization to M1 in Diabetes
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Identification and validation of key biomarkers and potential therapeutic targets for primary open-angle glaucoma
Primary open-angle glaucoma (POAG) is a prevalent cause of blindness worldwide, resulting in degeneration of retinal ganglion cells and permanent damage to the optic nerve. However, the underlying pathogenetic...
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Article
In-situ coating N-doped carbon on Co3O4 aerogel powders for remarkable supercapacitive properties
Sol-gel method combined with the freeze-drying method was applied to prepare Co3O4 aerogel powders (CAP). Subsequently, a nitrogen-doped carbon layer was encapsulated on the surface of the aerogel powder by carbo...
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Open AccessLow glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals, controlling metabolic states beyond energy metabolism. However, whether glycolytic metabolites also play a role in co...
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Open AccessAssociation between triglyceride glucose index and severity of diabetic foot ulcers in type 2 diabetes mellitus
Triglyceride glucose (TyG) index is a good surrogate biomarker to evaluate insulin resistance (IR). The study aimed to investigate whether the TyG index is related to the severity of diabetic foot ulcers (DFUs...
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Article
Open AccessMultimodal Analysis on Clinical Characteristics of the Advanced Stage in Myopic Traction Maculopathy
Here we investigate the clinical features of foveal detachment (FD), full-thickness macular hole (MH), and macular hole retinal detachment (MHRD) in myopic traction maculopathy (MTM).
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Article
Open AccessNF-κB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer
Adenoma-adenocarcinoma transition is a key feature of colorectal cancer (CRC) occurrence and is closely regulated by tumor-associated macrophages (TAMs) and CD8+ T cells. Here, we investigated the effect of the N...
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Open AccessPolymerizable rotaxane hydrogels for three-dimensional printing fabrication of wearable sensors
While hydrogels enable a variety of applications in wearable sensors and electronic skins, they are susceptible to fatigue fracture during cyclic deformations owing to their inefficient fatigue resistance. Her...
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Open AccessPreparation of laser microporous porcine acellular dermal matrix and observation of wound transplantation
To prepare a new type of porcine acellular dermis matrix (PADM) with the new laser microporous technique and verify its safety and feasibility. A novel porcine acellular dermis matrix (ADM) was prepared by usi...
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Open AccessDesign, methodology, and preliminary results of the non-human primates eye study
To describe the normative profile of ophthalmic parameters in a healthy cynomolgus monkey colony, and to identify the characteristic of the spontaneous ocular disease non-human primates (NHP) models.
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Effect of refractive status on retinal nerve fiber layer thickness in Chinese Population
To evaluate the relationship between retinal nerve fiber layer (RNFL) thickness and other related parameters measured by spectral-domain optical coherence tomography and the refractive error of eyes.
