12 Result(s)
within
C. Pacchetti
Psychiatry
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Article
Effect and safety of duodenal levodopa infusion in advanced Parkinson’s disease: a retrospective multicenter outcome assessment in patient routine care
Duodenal levodopa infusion represents an effective strategy to manage motor and non-motor complications in patients with advanced Parkinson’s disease (PD). However, most published clinical series regard small ...
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Article
How parkinsonism influences life: the patients’ point of view
To explore the experience of living with parkinsonism, a survey form was sent to the members of a patients’ association; 1,256 forms were analysed. The mean age was 65.75 ± 9.29 years; 64.4% males. A family hi...
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Article
Sleep disorders in Parkinson's disease: facts and new perspectives
Awareness of the clinical and pathophysiological importance of sleep disorders in Parkinson's disease (PD) has been growing in recent years. Sleep disorders are now regarded as important among non-motor sympto...
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A randomised, double-blind, dose-ranging study to evaluate efficacy and safety of three doses of botulinum toxin type A (Botox) for the treatment of spastic foot
Botulinum toxin A (BTX) injections have been used successfully in the treatment of post-stroke foot spasticity, but the optimal dose-response relationship for selected muscles has yet to be established. The ai...
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Article
Modifications of apoptosis-related protein levels in lymphocytes of patients with Parkinson’s disease. The effect of dopaminergic treatment
In this study, we investigated whether changes in the regulatory mechanisms of apoptosis and oxidative stress may be detected, peripherally, in patients with Parkinson’s disease (PD). For this purpose, we meas...
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Article
Comorbid disorders and hospitalisation in Parkinson’s disease: a prospective study
Parkinson’s disease (PD) is often associated with other disorders, typical of the disease or of the age of PD patients, that can lead to hospitalisation, sometimes as emergencies. In this one-year prospective,...
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Article
Sleep attacks in Parkinson’s disease: a clinical and polysomnographic study
The objective of the study was to evaluate daytime sleepiness, (the features of episodes of sudden sleep onset), i. e., so-called sleep attacks (SAs), in three male Parkinson’s disease (PD) patients (mean age ...
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Article
Modifications of plasma and platelet levels of L-DOPA and its direct metabolites during treatment with tolcapone or entacapone in patients with Parkinson’s disease
We compared – retrospectively – the effects of a 3-month therapy with catechol-O-methyltransferase (COMT) inhibitors tolcapone (100 mg, t.i.d.) and entacapone (200 mg, t.i.d.), on L-DOPA metabolism in two groups...
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Article
Parkinson's disease and reproductive life events
Onset, progression and duration of Parkinson's disease (PD) seem to be similar in men and women but gender differences have been suggested concerning clinical aspects, such as more severe disease in men and m...
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Article
Botulinum toxin treatment for functional disability induced by essential tremor
This study aimed to improve botulinum toxin's (BTX) efficacy and to reduce its unwanted effects in the treatment of functional disability due to essential tremor (ET) of the hand. Twenty patients with disabli...
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Article
Is seborrhea a sign of autonomic impairment in Parkinson's disease?
An increase of sebum excretion rate (SER) is frequently observed in patients suffering from Parkinson's disease (PD). Some authors attribute it to the hyperactivity of the parasympathetic system, while others ...
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Article
A multicenter Italian randomised study on early treatment of Parkinson disease: comparison of 1-dopa, 1-deprenyl and dopaminoagonists. Study design and short term results
On the long term Parkinson Disease (PD) treatment is often complicated by the occurrence of motor fluctuations. To find out whether early treatment of PD with levodopa, dopaminoagonists or 1-deprenyl is associ...
