8 Result(s)

Article

European recommendations and quality assurance for cytogenomic analysis of haematological neoplasms: reponse to the comments from the Francophone Group of Hematological Cytogenetics (GFCH)

K. A. Rack, E. van den Berg, C. Haferlach, H. B. Beverloo, D. Costa, B. Espinet… in Leukemia (2020)

Article

European recommendations and quality assurance for cytogenomic analysis of haematological neoplasms

Cytogenomic investigations of haematological neoplasms, including chromosome banding analysis, fluorescence in situ hybridisation (FISH) and microarray analyses have become increasingly important in the clinic...

K. A. Rack, E. van den Berg, C. Haferlach, H. B. Beverloo, D. Costa, B. Espinet… in Leukemia (2019)

Article

Assessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants

Chronic myeloid leukemia (CML)-study IV was designed to explore whether treatment with imatinib (IM) at 400 mg/day (n=400) could be optimized by doubling the dose (n=420), adding interferon (IFN) (n=430) or cytar...

R Hehlmann, M Lauseker, S Saußele, M Pfirrmann, S Krause, H J Kolb, A Neubauer… in Leukemia (2017)

Article

The molecular pathogenesis of the NUP98-HOXA9 fusion protein in acute myeloid leukemia

A Rio-Machin, G Gómez-López, J Muñoz, F Garcia-Martinez, A Maiques-Diaz… in Leukemia (2017)

Article

The new provisional WHO entity ‘RUNX1 mutated AML’ shows specific genetics but no prognostic influence of dysplasia

T Haferlach, A Stengel, S Eckstein, K Perglerová, T Alpermann, W Kern… in Leukemia (2016)

Article

The role of the RAS pathway in iAMP21-ALL

Intrachromosomal amplification of chromosome 21 (iAMP21) identifies a high-risk subtype of acute lymphoblastic leukaemia (ALL), requiring intensive treatment to reduce their relapse risk. Improved understandin...

S L Ryan, E Matheson, V Grossmann, P Sinclair, M Bashton, C Schwab, W Towers… in Leukemia (2016)

Article

Long-term outcome of patients with newly diagnosed chronic myeloid leukemia: a randomized comparison of stem cell transplantation with drug treatment

Tyrosine kinase inhibitors represent today’s treatment of choice in chronic myeloid leukemia (CML). Allogeneic hematopoietic stem cell transplantation (HSCT) is regarded as salvage therapy. This prospective ra...

A Gratwohl, M Pfirrmann, A Zander, N Kröger, D Beelen, J Novotny, C Nerl… in Leukemia (2016)

Article

Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

High-throughput DNA sequencing significantly contributed to diagnosis and prognostication in patients with myelodysplastic syndromes (MDS). We determined the biological and prognostic significance of genetic a...

T Haferlach, Y Nagata, V Grossmann, Y Okuno, U Bacher, G Nagae, S Schnittger… in Leukemia (2014)