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within C. A. J. Knibbe Remove this filter English Remove this filter Metabolic Diseases Remove this filter

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  1. Article

    Open Access

    Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study

    Off-label metformin is nowadays frequently used for the treatment of obesity in adolescents. However, studies on long-term metformin treatment in adolescents with obesity are scarce. Therefore, an 18 month ope...

    Y. E. Lentferink, M. P. van der Aa, E. G. A. H. van Mill… in Nutrition & Diabetes (2018)

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  2. Article

    Open Access

    Long-term treatment with metformin in obese, insulin-resistant adolescents: results of a randomized double-blinded placebo-controlled trial

    As adolescents with obesity and insulin resistance may be refractory to lifestyle intervention therapy alone, additional off-label metformin therapy is often used. In this study, the long-term efficacy and saf...

    M P van der Aa, M A J Elst, E M W van de Garde, E G A H van Mil… in Nutrition & Diabetes (2016)

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  3. Article

    Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches

    This study aimed to systematically review what has been reported on the incidence and prevalence of type 2 diabetes in children and adolescents, to scrutinise the methodological issues observed in the included...

    S. Fazeli Farsani, M. P. van der Aa, M. M. J. van der Vorst… in Diabetologia (2013)

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