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  1. Article

    Open Access

    Patients with Obesity Should be Recognised as a Special Patient Population During Drug Development of Antibacterial and Antifungal Agents; A Call to Action

    Individuals with obesity are at increased risk of develo** infectious diseases. Timely administration of an effective dose of an antimicrobial agent is paramount to safeguard optimal therapy. For this purpos...

    K. P. van Rhee, C. A. J. Knibbe, P. D. van der Linden… in Clinical Pharmacokinetics (2024)

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  2. No Access

    Article

    Efficacy of Metformin Treatment with Respect to Weight Reduction in Children and Adults with Obesity: A Systematic Review

    Obesity and its related complications are increasing health issues. Since generally only minor weight loss is obtained with lifestyle intervention, additional pharmacological therapies such as metformin are of...

    Y. E. Lentferink, C. A. J. Knibbe, M. M. J. van der Vorst in Drugs (2018)

  3. Article

    Open Access

    Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study

    Off-label metformin is nowadays frequently used for the treatment of obesity in adolescents. However, studies on long-term metformin treatment in adolescents with obesity are scarce. Therefore, an 18 month ope...

    Y. E. Lentferink, M. P. van der Aa, E. G. A. H. van Mill… in Nutrition & Diabetes (2018)

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  4. Article

    Open Access

    Long-term treatment with metformin in obese, insulin-resistant adolescents: results of a randomized double-blinded placebo-controlled trial

    As adolescents with obesity and insulin resistance may be refractory to lifestyle intervention therapy alone, additional off-label metformin therapy is often used. In this study, the long-term efficacy and saf...

    M P van der Aa, M A J Elst, E M W van de Garde, E G A H van Mil… in Nutrition & Diabetes (2016)

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  5. Article

    Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches

    This study aimed to systematically review what has been reported on the incidence and prevalence of type 2 diabetes in children and adolescents, to scrutinise the methodological issues observed in the included...

    S. Fazeli Farsani, M. P. van der Aa, M. M. J. van der Vorst… in Diabetologia (2013)

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  6. Article

    298 Cd3+Cd4+-Lymphocytes as Biomarker Predicting the Outcome of Pediatric Haematopoietic Stem Cell Transplantation Recipients

    Introduction: Haematopoietic stem cell transplantation (HSCT) may be complicated by severe infectious complications, graft-versus-host disease (GvHD) and relapse/graft failures depending on the lymphocyte immu...

    I Bartelink, S V Belitser, C A J Knibbe, M Danhof, P J De Pagter… in Pediatric Research (2010)

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