1 Result(s)

Article

A caspase-3 ‘death-switch’ in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers

Novel anticancer drugs targeting key apoptosis regulators have been developed and are undergoing clinical trials. Pharmacodynamic biomarkers to define the optimum dose of drug that provokes tumor apoptosis are...

K L Simpson, C Cawthorne, C Zhou, C L Hodgkinson, M J Walker… in Cell Death & Disease (2013)