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Article
Open AccessThe endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria
Components of the death receptor-mediated pathways like caspase-8 have been identified in complexes at intracellular membranes to spatially restrict the processing of local targets. In this study, we report th...
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Article
Open Accessc-Flip overexpression affects satellite cell proliferation and promotes skeletal muscle aging
This study shows that forcing c-Flip overexpression in undifferentiated skeletal myogenic cells in vivo results in early aging muscle phenotype. In the transgenic mice, adult muscle histology, histochemistry and ...
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Article
FLIP is expressed in mouse testis and protects germ cells from apoptosis
Apoptosis control in adult testis is crucial to achieve normal spermatogenesis. In this study c-FLIP, an apoptosis-modulating protein, was investigated. In Western blot and immunohistochemical analyses, the 55...
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Article
E1A stimulates FGF-2 release promoting differentiation of primary endothelial cells
Basic Fibroblast Growth Factor (FGF-2) is a growth and survival factor and represents one of the most potent differentiation agents of vascular system. In the present study we describe that adenoviral oncoprot...