7 Result(s)
within
Bruce E Elliott
Oncology
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Article
Open AccessIntravital imaging reveals systemic ezrin inhibition impedes cancer cell migration and lymph node metastasis in breast cancer
Limited understanding of the cancer biology of metastatic sites is a major factor contributing to poor outcomes in cancer patients. The regional lymph nodes are the most common site of metastasis in most solid...
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Article
Open AccessErratum to: “A novel role for ezrin in breast cancer angio/lymphangiogenesis”
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Article
Open AccessA novel role for ezrin in breast cancer angio/lymphangiogenesis
Recent evidence suggests that tumour lymphangiogenesis promotes lymph node metastasis, a major prognostic factor for survival of breast cancer patients. However, signaling mechanisms involved in tumour-induced...
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Article
Open AccessEzrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells
The membrane cytoskeletal crosslinker, ezrin, a member of the ERM family of proteins, is frequently over-expressed in human breast cancers, and is required for motility and invasion of epithelial cells. Our gr...
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Article
Open AccessA novel activating role of SRC and STAT3 on HGF transcription in human breast cancer cells
We have previously determined that the HGF promoter can be transactivated by a combination of activated Src and wild-type Stat3 in the mouse breast cell lines HC11 and SP1. To determine if this pathway is of r...
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Article
Open AccessThe membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells
The membrane cytoskeletal crosslinker ezrin participates in several functions including cell adhesion, motility and cell survival, and there is increasing evidence that it regulates tumour progression. However...
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Tumor specific antigens induced by mutagens and DNA hypomethylating agents: implications for the immunobiology of neoplasia
The effusive enthusiasm that characterized so much of tumor immunology research during the 1960’s and 1970’s has gradually given way to a widespread and pervasive cynicism. One could cite many reasons for this...
