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within Brian A. Yee Remove this filter Biochemistry, general Remove this filter Membrane Biology Remove this filter

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  1. No Access

    Article

    Large-scale tethered function assays identify factors that regulate mRNA stability and translation

    The molecular functions of the majority of RNA-binding proteins (RBPs) remain unclear, highlighting a major bottleneck to a full understanding of gene expression regulation. Here, we develop a plasmid resource...

    En-Ching Luo, Jason L. Nathanson, Frederick E. Tan… in Nature Structural & Molecular Biology (2020)

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    Article

    Short poly(A) tails are a conserved feature of highly expressed genes

    Although deadenylation induces translational inhibition and mRNA decay, well-expressed transcripts are now shown to possess short, well-defined poly(A) tails, suggesting that pruned tails may be ideal for prot...

    Sarah Azoubel Lima, Laura B Chipman… in Nature Structural & Molecular Biology (2017)

  3. No Access

    Article

    RNA-binding protein CPEB1 remodels host and viral RNA landscapes

    The RNA-binding protein CPEB1 drives post-transcriptional changes in the host transcriptome and poly(A)-tail lengthening of viral RNAs, processes essential for productive HCMV infection.

    Ranjan Batra, Thomas J Stark, Alex E. Clark… in Nature Structural & Molecular Biology (2016)