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IL-8 and p53 are inversely regulated through JNK, p38 and NF-κB p65 in HepG2 cells during an inflammatory response

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  1. Article

    Open Access

    Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

    Dimethyl fumarate (DMF) has been applied for decades in the treatment of psoriasis and now also multiple sclerosis. However, the mechanism of action has remained obscure and involves high dose over long time o...

    Jacob Lauwring Andersen, Borbala Gesser, Erik Daa Funder… in Nature Communications (2018)

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  2. Chapter

    Human Cellular Protein Patterns and Their Link to Genome DNA Map** and Sequencing Data: Towards an Integrated Approach to the Study of Gene Expression

    The haploid human genome consists of 3 × 109 base pairs of DNA distributed in 23 distinct chromosomes. Current estimates indicate that there are about 50,000 to 100,000 genes with perhaps 2,000 to 4,000 genes in ...

    Julio E. Celis, Hanne H. Rasmussen, Henrik Leffers, Peder Madsen… in Genetic Engineering (1993)

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