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Article
Gene-Centric Analysis of Serum Cotinine Levels in African and European American Populations
To date, most genetic association studies of tobacco use have been conducted in European American subjects using the phenotype of smoking quantity (cigarettes per day). However, smoking quantity is a very impr...
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Article
Open AccessMeasuring smoking-related preoccupation and compulsive drive: evaluation of the obsessive compulsive smoking scale
Tobacco use for many people is compulsive in nature. Compelling theories of how smoking becomes compulsive exist but are largely based on extrapolation from neuroscience findings. Research on smokers is impede...
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Article
Open AccessImpulsivity and cigarette craving: differences across subtypes
Cigarette smoking has been linked to a number of personality characteristics, including impulsivity. Smokers tend to endorse high levels of impulsivity, and more impulsive smokers have greater difficulty quitt...
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Article
Abuse potential of carbohydrates for overweight carbohydrate cravers
The long-rejected construct of food addiction is undergoing re-examination.
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Article
Nicotine effects on affective response in depression-prone smokers
Comorbidity between cigarette smoking and depression is thought to arise because depression-prone smokers self-administer nicotine to improve mood. Yet little evidence supports this view, and nicotine’s effect...
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Article
Effect of impulsivity on craving and behavioral reactivity to smoking cues
Nearly 25% of American adults remain regular smokers. Current smokers may be especially likely to possess characteristics that impair their ability to quit, such as impulsivity. Impulsive individuals may be ov...
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Article
Effect of tryptophan depletion on the attentional salience of smoking cues
There is increasing evidence linking cigarette craving and smoking behavior to serotonergic neurotransmission.
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Article
Influence of nicotine on positive affect in anhedonic smokers
The possibility that individuals administer nicotine to self-regulate persistent negative affect has received interest as a possible explanation for the high prevalence of affectively vulnerable smokers. Relat...
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Article
Effects of Acute Tryptophan Depletion on Negative Symptoms and Smoking Topography in Nicotine-Dependent Schizophrenics and Nonpsychiatric Controls
We studied the effect of acute tryptophan depletion (ATD), which transiently reduces brain serotonin, on negative symptoms and cigarette smoking topography in schizophrenic smokers. Nicotine-dependent schizoph...
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Article
Influence of fluoxetine on positive and negative affect in a clinic-based smoking cessation trial
Fluoxetine improves affect in clinical syndromes such as depression and premenstrual dysphoric disorder. Little is known about fluoxetine’s influence on mood changes after quitting smoking, which often resembl...
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Article
Amitriptyline, clovoxamine and cognitive function: a placebo-controlled comparison in depressed outpatients
No longer prescribed only for vegetative signs of depression, tricyclic antidepressants also lessen depressive cognitive distortions. Less clear is whether they ameliorate depressed patients' other cognitive d...
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Article
Effects of two antidepressants on memory performance in depressed outpatients: a double-blind study
Forty outpatients with primary depression were randomly assigned on a double-blind basis to treatment with amitriptyline (a tricyclic antidepressant) or clovoxamine (a nontricyclic, experimental antidepressant...