![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Open AccessSusceptibility gene identification and risk evaluation model construction by transcriptome-wide association analysis for salt sensitivity of blood pressure
Salt sensitivity of blood pressure (SSBP) is an intermediate phenotype of hypertension and is a predictor of long-term cardiovascular events and death. However, the genetic structures of SSBP are uncertain, an...
-
Article
Open AccessThe role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment: a review
Pulmonary fibrosis (PF) is a progressive interstitial inflammatory disease with a high mortality rate. Patients with PF commonly experience a chronic dry cough and progressive dyspnoea for years without effect...
-
Article
Open AccessNeutralizing IL-16 enhances the efficacy of targeting Aurora-A therapy in colorectal cancer with high lymphocyte infiltration through restoring anti-tumor immunity
Cancer cells can evade immune elimination by activating immunosuppressive signaling pathways in the tumor microenvironment (TME). Targeting immunosuppressive signaling pathways to promote antitumor immunity ha...
-
Article
Open AccessIdentification of WUSCHEL-related homeobox gene and truncated small peptides in transformation efficiency improvement in Eucalyptus
The WUSCHEL-related Homeobox (WOX) genes, which encode plant-specific homeobox (HB) transcription factors, play crucial roles in regulating plant growth and development. However, the functions of WOX genes are li...
-
Article
Open AccessThe p53/ZEB1-PLD3 feedback loop regulates cell proliferation in breast cancer
Breast cancer is the most prevalent cancer globally, endangering women’s physical and mental health. Phospholipase D3 (PLD3) belongs to the phosphodiesterase family (PLD). PLD3 is related to insulin-mediated p...
-
Article
Open AccessAuthor Correction: Genomic insights into biased allele loss and increased gene numbers after genome duplication in autotetraploid Cyclocarya paliurus
-
Article
Open AccessGenomic insights into biased allele loss and increased gene numbers after genome duplication in autotetraploid Cyclocarya paliurus
Autopolyploidy is a valuable model for studying whole-genome duplication (WGD) without hybridization, yet little is known about the genomic structural and functional changes that occur in autopolyploids after ...
-
Article
Selenium Deficiency Leads to Reduced Skeletal Muscle Cell Differentiation by Oxidative Stress in Mice
Selenium (Se) is one of the essential trace elements in animal organisms with good antioxidant and immune-enhancing abilities. In this study, we investigated the effect and mechanism of Se deficiency on skelet...
-
Article
Correction: Global deletion of optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget’s disease
-
Article
Open AccessHuman umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis
Erectile dysfunction (ED), as one of the most prevalent consequences in male diabetic patients, has a serious impact on men's physical and mental health, and the treatment effect of diabetic mellitus erectile ...
-
Article
Open AccessTDP-43 upregulates lipid metabolism modulator ABHD2 to suppress apoptosis in hepatocellular carcinoma
TAR DNA-Binding Protein 43 (TDP-43) has been well studied in neurodegenerative diseases, but its potential role in malignance is still unclear. Here, we demonstrate that TDP-43 contributes to the suppression o...
-
Article
Open AccessThe resistance of peanut to soil-borne pathogens improved by rhizosphere probiotics under calcium treatment
Peanut (Arachis hypogaea L.) is an important oil and economic crop. Calcium modulates plants in response to abiotic stresses and improves plant resistance to pathogens. Enrichment of beneficial microorganisms in ...
-
Article
Open AccessThe nuclear bodies formed by histone demethylase KDM7A
-
Article
Correction: Global deletion of optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget’s disease
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Genome-wide identification and expression analysis of the CLC superfamily genes in tea plants (Camellia sinensis)
The voltage-gated chloride channel (CLC) superfamily is one of the most important anion channels that is widely distributed in bacteria and plants. CLC is involved in transporting various anions such as chlori...
-
Article
Aluminum relieves fluoride stress through stimulation of organic acid production in Camellia sinensis
Tea plants (Camellia sinensis O. Kuntze) can hyperaccumulate fluoride (F) in leaves. Although, aluminum (Al) can alleviate F toxicity in C. sinensis, the mechanisms driving this process remain unclear. Here, we m...
-
Article
Characteristics of soil nutrients, heavy metals and tea quality in different intercrop** patterns
Intercrop** is an important agroforestry practice that can not only increase biodiversity, improve microenvironment and resource utilization, but also improve crop yield and quality. In this paper, the soil ...
-
Article
Screening of Biomarkers Related to Ovarian Maturation and Spawning in Blunt Snout Bream (Megalobrama amblycephala) Based on Metabolomics and Transcriptomics
In fish breeding practices, gamete maturity of females is vital to reproductive success. For some species, it is possible to estimate the female maturation status based on abdomen observation, but quite diffic...
-
Article
Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget’s disease
Genome-wide association studies (GWAS) have identified Optineurin (OPTN) as genetically linked to Paget’s disease of the bone (PDB), a chronic debilitating bone remodeling disorder characterized by localized area...
-
Article
Effects of soybean–tea intercrop** on soil-available nutrients and tea quality
Plant intercrop** is increasing in popularity, is conducive to plant growth and development and can improve plant quality and yield. In this study, we intercropped tea (Camellia sinensis) cv. ‘Su cha zao’ and s...