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Article
Open AccessscFSNN: a feature selection method based on neural network for single-cell RNA-seq data
While single-cell RNA sequencing (scRNA-seq) allows researchers to analyze gene expression in individual cells, its unique characteristics like over-dispersion, zero-inflation, high gene-gene correlation, and ...
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Article
Protective Role of Endothelial SIRT1 in Deep Vein Thrombosis and Hypoxia-induced Endothelial Dysfunction Mediated by NF-κB Deacetylation
Venous hypoxia is considered as the major pathogenetic mechanism linking blood flow stagnancy with deep vein thrombosis (DVT). Our previous study showed that activating SIRT1 may attenuate inferior vena cava (...
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Article
Maximum nonparametric kernel likelihood estimation for multiplicative linear regression models
We propose a kernel density based estimation for multiplicative linear regression models. The method proposed in this article makes use of kernel smoothing nonparametric techniques to estimate the unknown dens...
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Article
Aqueous extract of Whitmania pigra Whitman ameliorates ferric chloride-induced venous thrombosis in rats via antioxidation
Whitmania pigra Whitman (W. pigra) has been widely employed in decoction for the treatment of blood stasis syndrome for many years in China. The aim of the present study was to explore the anti-venous thrombosis ...
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Smart Building Sensor Drift Calibration
In modern smart buildings, the temperature measurement is crucial for smart temperature management implemented by a cyber-physical system (CPS). However, sensor drift emerges during the measurement and becomes...
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Article
Open AccessA statistical normalization method and differential expression analysis for RNA-seq data between different species
High-throughput techniques bring novel tools and also statistical challenges to genomic research. Identifying genes with differential expression between different species is an effective way to discover evolut...
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Article
Open AccessStability of methods for differential expression analysis of RNA-seq data
As RNA-seq becomes the assay of choice for measuring gene expression levels, differential expression analysis has received extensive attentions of researchers. To date, for the evaluation of DE methods, most a...
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Article
Stable prediction in high-dimensional linear models
We propose a Random Splitting Model Averaging procedure, RSMA, to achieve stable predictions in high-dimensional linear models. The idea is to use split training data to construct and estimate candidate models...
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Article
Open AccessHigh-resolution RNA alleloty** along the inactive X chromosome: evidence of RNA polymerase III in regulating chromatin configuration
We carried out padlock capture, a high-resolution RNA alleloty** method, to study X chromosome inactivation (XCI). We examined the gene reactivation pattern along the inactive X (**), after **st (X-inactive spe...
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Article
Open AccessLFCseq: a nonparametric approach for differential expression analysis of RNA-seq data
With the advances in high-throughput DNA sequencing technologies, RNA-seq has rapidly emerged as a powerful tool for the quantitative analysis of gene expression and transcript variant discovery. In comparativ...
