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  1. Article

    Open Access

    scFSNN: a feature selection method based on neural network for single-cell RNA-seq data

    While single-cell RNA sequencing (scRNA-seq) allows researchers to analyze gene expression in individual cells, its unique characteristics like over-dispersion, zero-inflation, high gene-gene correlation, and ...

    Minjiao Peng, Baoqin Lin, Jun Zhang, Yan Zhou, Bingqing Lin in BMC Genomics (2024)

  2. Article

    Open Access

    A statistical normalization method and differential expression analysis for RNA-seq data between different species

    High-throughput techniques bring novel tools and also statistical challenges to genomic research. Identifying genes with differential expression between different species is an effective way to discover evolut...

    Yan Zhou, Jiadi Zhu, Tiejun Tong, Junhui Wang, Bingqing Lin in BMC Bioinformatics (2019)

  3. Article

    Open Access

    Stability of methods for differential expression analysis of RNA-seq data

    As RNA-seq becomes the assay of choice for measuring gene expression levels, differential expression analysis has received extensive attentions of researchers. To date, for the evaluation of DE methods, most a...

    Bingqing Lin, Zhen Pang in BMC Genomics (2019)

  4. Article

    Open Access

    LFCseq: a nonparametric approach for differential expression analysis of RNA-seq data

    With the advances in high-throughput DNA sequencing technologies, RNA-seq has rapidly emerged as a powerful tool for the quantitative analysis of gene expression and transcript variant discovery. In comparativ...

    Bingqing Lin, Li-Feng Zhang, **n Chen in BMC Genomics (2014)