1,258 Result(s)
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Bing-** Yan
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Article
Open AccessSodium tanshinone IIA sulfonate protects vascular relaxation in ApoE-knockout mice by inhibiting the SYK-NLRP3 inflammasome-MMP2/9 pathway
Hyperlipidemia damages vascular wall and serves as a foundation for diseases such as atherosclerosis, hypertension and stiffness. The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is ...
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Open AccessAn 18-gene signature of recurrence-associated endothelial cells predicts tumor progression and castration resistance in prostate cancer
The prognostic and therapeutic implications of endothelial cells (ECs) heterogeneity in prostate cancer (PCa) are poorly understood.
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Open AccessStable peptide-assembled nanozyme mimicking dual antifungal actions
Natural antimicrobial peptides (AMPs) and enzymes (AMEs) are promising non-antibiotic candidates against antimicrobial resistance but suffer from low efficiency and poor stability. Here, we develop peptide nan...
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Open AccessUnraveling the energy storage mechanism in graphene-based nonaqueous electrochemical capacitors by gap-enhanced Raman spectroscopy
Graphene has been extensively utilized as an electrode material for nonaqueous electrochemical capacitors. However, a comprehensive understanding of the charging mechanism and ion arrangement at the graphene/e...
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Targeting pericentric non-consecutive motifs for heterochromatin initiation
Pericentric heterochromatin is a critical component of chromosomes marked by histone H3 K9 (H3K9) methylation1–3. However, what recruits H3K9-specific histone methyltransferases to pericentric regions in vertebra...
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Associations between atherosclerotic luminal stenosis in the distal internal carotid artery and diffuse wall thickening in its upstream segment
Significant atherosclerotic stenosis or occlusion in the distal internal carotid artery (ICA) may induce diffuse wall thickening (DWT) in the upstream arterial wall. This study aimed to assess the association ...
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Enhanced electrochemical performance of PEO/Li6.4Ga0.2La3Zr2O12 composite polymer electrolytes
All-solid-state lithium batteries (ASSLBs) are regarded as the most promising alternative to traditional liquid lithium-ion batteries due to their high-energy density and excellent safety. As an important part...
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Open AccessIntraoperative urinary tract resection and construction in CRS + HIPEC procedures: a single center retrospective analysis
The safety and efficacy of CRS + HIPEC combined with urinary tract resection and reconstruction are controversial. This study aims to summarize the clinicopathological features and to evaluate the safety and s...
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Open AccessDietary ellagic acid therapy for CNS autoimmunity: Targeting on Alloprevotella rava and propionate metabolism
Mediterranean diet rich in polyphenolic compounds holds great promise to prevent and alleviate multiple sclerosis (MS), a central nervous system autoimmune disease associated with gut microbiome dysbiosis. Hea...
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Effect of phase content on deformation compatibility in ferrite and bainite dual-phase steel: experimental and crystal plasticity finite element analysis
The phase volume fraction has an important role in the match of the strength and plasticity of dual phase steel. The different bainite contents (18–53 vol.%) in polygonal ferrite and bainite (PF + B) dual phas...
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Open AccessIL-37d suppresses Rheb-mTORC1 axis independently of TCS2 to alleviate alcoholic liver disease
Tuberous sclerosis complex 2 (TSC2) crucially suppresses Rheb activity to prevent mTORC1 activation. However, mutations in TSC genes lead to mTORC1 overactivation, thereby causing various developmental disorde...
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Associations of toxic metals and their mixture with hyperuricemia in Chinese rural older adults
Previous studies have related single toxic metals (TMs) to hyperuricemia (HUA) among the general population, however, the association of the TM mixture with HUA, especially in older adults, remains poorly unde...
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Fluorescence Sensing Properties of a Bibranched Cyanostilbene Derivative Containing -NH2 for Trace Water and Picric Acid Determination
In order to design organic small molecule fluorescent materials with multiple sensing, a bibranched -NH2 modified cyanostilbene derivative (AM) was synthesized. It exhibits solvent and aggregation-induced emissio...
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Open AccessRecent advances in the application of [2 + 2] cycloaddition in the chemical synthesis of cyclobutane-containing natural products
Cyclobutanes are distributed widely in a large class of natural products featuring diverse pharmaceutical activities and intricate structural frameworks. The [2 + 2] cycloaddition is unequivocally the primary ...
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Yersinia infection induces glucose depletion and AMPK-dependent inhibition of pyroptosis in mice
Nutritional status and pyroptosis are important for host defence against infections. However, the molecular link that integrates nutrient sensing into pyroptosis during microbial infection is unclear. Here, us...
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A Janus dual-atom catalyst for electrocatalytic oxygen reduction and evolution
Dual-atom catalysts, which exhibit high activity and atom utilization, show promise for sustainable energy conversion and storage technologies. However, the rational design and synthesis of a dual-atom catalys...
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Association between baseline office blood pressure level and the incidence and development of long-term frailty in the community-dwelling very elderly with hypertension
Frailty is the most important risk factor causing disability in the elderly. Hypertension is one of the most common chronic diseases in the elderly and is closely related to frailty, but there is still controv...
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Self-assembled high-entropy nitride multilayer coating
The development of advanced materials and construction of multilayer structure contribute to enhancing the performance of protective coatings, further improving the industrial productivity and conserving energ...
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Integrating climate–pest interactions into crop projections for sustainable agriculture
Crop pest invasions and their interactions with climate change may have been overlooked in crop yield projections, hindering the development of climate-resilient and sustainable agriculture. A harmonized strat...
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Two new sesterterpenoids from Atractylodes japonica Koidz. ex Kitam
Two new sesterterpenoids, atractylodes japonica terpenoid acid I (1) and atractylodes japonica terpenoid aldehyde I (2), were isolated from the rhizomes of Atractylodes japonica Koidz. ex Kitam together with ten ...
