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  1. Article

    Open Access

    Ganglioside SSEA-4 in Ewing sarcoma marks a tumor cell population with aggressive features and is a potential cell-surface immune target

    Carbohydrate markers of immature cells during prenatal human development can be aberrantly expressed in cancers and deserve evaluation as immune targets. A candidate target in Ewing sarcoma is the globo-series...

    Silke Jamitzky, Bianca Altvater, Carolin Krekeler, Laura Hoen… in Scientific Reports (2024)

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  2. Article

    Open Access

    CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process

    To enhance the potency of chimeric antigen receptor (CAR) engineered T cells in solid cancers, we designed a novel cell-based combination strategy with an additional therapeutic mode of action. CAR T cells are...

    Bianca Altvater, Sareetha Kailayangiri, Christian Spurny… in Cancer Gene Therapy (2023)

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  3. No Access

    Article

    Common Ewing sarcoma-associated antigens fail to induce natural T cell responses in both patients and healthy individuals

    Disseminated or relapsed Ewing sarcoma (EwS) has remained fatal in the majority of patients. A promising approach to preventing relapse after conventional therapy is to establish tumor antigen-specific immune ...

    Bianca Altvater, Sareetha Kailayangiri, Nadine Theimann… in Cancer Immunology, Immunotherapy (2014)

  4. No Access

    Article

    Activated human γδ T cells induce peptide-specific CD8+ T-cell responses to tumor-associated self-antigens

    Specific cellular immunotherapy of cancer requires efficient generation and expansion of cytotoxic T lymphocytes (CTLs) that recognize tumor-associated self-antigens. Here, we investigated the capacity of huma...

    Bianca Altvater, Sibylle Pscherer, Silke Landmeier… in Cancer Immunology, Immunotherapy (2012)

  5. No Access

    Protocol

    T Bodies

    Genetic modification of T cells with antigen-specific chimeric receptors (CARs) has great potential to redirect their effector functions to a wide variety of therapeutic targets, including weakly expressed or ...

    Bianca Altvater, Silke Landmeier, Claudia Rossig in Antibody Engineering (2010)

  6. No Access

    Article

    2B4 (CD244) signaling via chimeric receptors costimulates tumor-antigen specific proliferation and in vitro expansion of human T cells

    Regulatory NK cell receptors can contribute to antigen-specific adaptive immune responses by modulating T cell receptor (TCR)-induced T cell activation. We investigated the potential of the NK cell receptor 2B...

    Bianca Altvater, Silke Landmeier, Sibylle Pscherer… in Cancer Immunology, Immunotherapy (2009)