1,699 Result(s)
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Open AccessConsistency, completeness and external validity of ethnicity recording in NHS primary care records: a cohort study in 25 million patients’ records at source using OpenSAFELY
Ethnicity is known to be an important correlate of health outcomes, particularly during the COVID-19 pandemic, where some ethnic groups were shown to be at higher risk of infection and adverse outcomes. The re...
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Open AccessNovel drug resistance mechanisms and drug targets in BRAF-mutated peritoneal metastasis from colorectal cancer
Patients with peritoneal metastasis from colorectal cancer (PM-CRC) have inferior prognosis and respond particularly poorly to chemotherapy. This study aims to identify the molecular explanation for the observ...
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Association of HLA-G 3′UTR polymorphisms with hepatitis B virus infection in Tunisian population
Hepatitis B virus (HBV) infection is a major public health burden. The mechanisms of immune evasion during chronic HBV (CHB) infection are poorly understood. Human leukocyte antigen (HLA)-G, an immune checkpoi...
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Open AccessA systematic umbrella review and meta-meta-analysis of eHealth and mHealth interventions for improving lifestyle behaviours
The aim of this meta-meta-analysis was to systematically review randomised controlled trial (RCT) evidence examining the effectiveness of e- and m-Health interventions designed to improve physical activity, se...
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Open AccessRisk of emergency hospital admission related to adverse events after antibiotic treatment in adults with a common infection: impact of COVID-19 and derivation and validation of risk prediction models
With the global challenge of antimicrobial resistance intensified during the COVID-19 pandemic, evaluating adverse events (AEs) post-antibiotic treatment for common infections is crucial. This study aims to ex...
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Improved CAR-T cell activity associated with increased mitochondrial function primed by galactose
CD19 CAR-T cells have led to durable remissions in patients with refractory B-cell malignancies; nevertheless, most patients eventually relapse in the long term. Many interventions aimed at improving current p...
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Curcumin Interferes with TGF- β 1-Induced Fibrosis in NRK-49F Cells by Reversing ADAMTS18 Gene Methylation
To explore the molecular mechanism by which curcumin affects renal interstitial fibrosis (RIF) progression by regulating ADAM metallopeptidase with thrombospondin type 1 motif 18 (ADAMTS18) methylation.
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Completeness of intervention reporting of nutrition-focused weight management interventions adjunct to metabolic and bariatric surgery: effect of the TIDieR checklist
Nutrition-focused interventions are essential to optimize the bariatric care process and improve health and weight outcomes over time. Clear and detailed reporting of these interventions in research reports is...
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Open AccessBarriers and enablers to promoting grandchildren’s physical activity and reducing screen time: a qualitative study with Australian grandparents
With an increasing number of grandparents providing care to their grandchildren, calls have been made for these caregivers to be considered important stakeholders in encouraging children’s engagement in health...
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Open AccessHealthcare utilisation in people with long COVID: an OpenSAFELY cohort study
Long COVID potentially increases healthcare utilisation and costs. However, its impact on the NHS remains to be determined.
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Open AccessHigh capacity clinical SARS-CoV-2 molecular testing using combinatorial pooling
The SARS-CoV-2 pandemic led to unprecedented testing demands, causing major testing delays globally. One strategy used for increasing testing capacity was pooled-testing, using a two-stage technique first intr...
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Open AccessHepatic myelopathy neurological complication of chronic liver disease: two case reports
Hepatic myelopathy is a very rare neurological complication of chronic liver disease. Patients habitually present with progressive pure motor spastic paraparesis. This neurological dysfunction is almost always...
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Open AccessAdvances in fetal and neonatal neuroimaging and everyday exposures
The complex, tightly regulated process of prenatal brain development may be adversely affected by “everyday exposures” such as stress and environmental pollutants. Researchers are only just beginning to unders...
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Open AccessAssociation of post-COVID phenotypic manifestations with new-onset psychiatric disease
Acute COVID-19 infection can be followed by diverse clinical manifestations referred to as Post Acute Sequelae of SARS-CoV2 Infection (PASC). Studies have shown an increased risk of being diagnosed with new-on...
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Open AccessThe importance of vision care for displaced populations: lessons from Israeli evacuees
This study explores vision care priorities and co** mechanisms for Israeli evacuees and following the October 7th, 2023, attack by Hamas, which displaced 150,000 individuals, with about 15,000 being evacuate...
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Open AccessOcular and orbital manifestations in VEXAS syndrome
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is a hematoinflammatory disease that typically affects adults. It results from a somatic mutation of the E1 ubiquitin conjugating enzyme encoded...
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Open AccessBack to the Future: A Case of Severe ARDS Responsive to Shunned Therapies, A Review of the Past, and a Road Map to Future Investigations
The COVID-19 pandemic served as a reminder of the limited treatments available for acute respiratory distress syndrome (ARDS). The pandemic has highlighted the need to identify different clinical phenotypes of...
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Open AccessBiofilm Formation by Hospital-Acquired Resistant Bacteria Isolated from Respiratory Samples
Hospital-acquired resistant infections (HARI) are infections, which develop 48 h or more after admission to a healthcare facility. HARI pose a considerably acute challenge, due to limited treatment options. Th...
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Open AccessA comprehensive analysis of minimally differentially methylated regions common to pediatric and adult solid tumors
Cancer is the second most common cause of death in children aged 1–14 years in the United States, with 11,000 new cases and 1200 deaths annually. Pediatric cancers typically have lower mutational burden compar...
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Open AccessTowards automatic home-based sleep apnea estimation using deep learning
Apnea and hypopnea are common sleep disorders characterized by the obstruction of the airways. Polysomnography (PSG) is a sleep study typically used to compute the Apnea-Hypopnea Index (AHI), the number of tim...
