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MK2206 overcomes the resistance of human liver cancer stem cells to sorafenib by inhibition of pAkt and upregulation of pERK

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  1. Article

    Open Access

    Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells

    1,2:5,6-Dianhydrogalactitol (DAG) is a bi-functional DNA-targeting agent currently in phase II clinical trial for treatment of temozolomide-resistant glioblastoma (GBM). In the present study, we investigated t...

    Beibei Zhai, Yue Li, Sudha Sravanti Kotapalli, Jeffrey Bacha… in Cell Death & Disease (2020)

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  2. Article

    Open Access

    Dianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination

    1,2:5,6-Dianhydrogalactitol (DAG) is a bifunctional DNA-targeting agent causing N7-guanine alkylation and inter-strand DNA crosslinks currently in clinical trial for treatment of glioblastoma. While preclinical s...

    Beibei Zhai, Anne Steinø, Jeffrey Bacha, Dennis Brown… in Cell Death & Disease (2018)

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  3. Article

    Open Access

    Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines

    Cancer stem cells (CSCs) are regarded as the cause of tumor formation and recurrence. The isolation and identification of CSCs could help to develop novel therapeutic strategies specifically targeting CSCs.

    Lu Cao, Yanming Zhou, Beibei Zhai, Jian Liao, Wen Xu, Ruixiu Zhang… in BMC Gastroenterology (2011)

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