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  1. Article

    Open Access

    Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells

    1,2:5,6-Dianhydrogalactitol (DAG) is a bi-functional DNA-targeting agent currently in phase II clinical trial for treatment of temozolomide-resistant glioblastoma (GBM). In the present study, we investigated t...

    Beibei Zhai, Yue Li, Sudha Sravanti Kotapalli, Jeffrey Bacha… in Cell Death & Disease (2020)

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  2. Article

    Open Access

    Dianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination

    1,2:5,6-Dianhydrogalactitol (DAG) is a bifunctional DNA-targeting agent causing N7-guanine alkylation and inter-strand DNA crosslinks currently in clinical trial for treatment of glioblastoma. While preclinical s...

    Beibei Zhai, Anne Steinø, Jeffrey Bacha, Dennis Brown… in Cell Death & Disease (2018)

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