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2 Result(s)

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  1. No Access

    Article

    A Mechanism-based Disease Progression Model for Comparison of Long-term Effects of Pioglitazone, Metformin and Gliclazide on Disease Processes Underlying Type 2 Diabetes Mellitus

    Effective long-term treatment of Type 2 Diabetes Mellitus (T2DM) implies modification of the disease processes that cause this progressive disorder. This paper proposes a mechanism-based ...

    Willem de Winter, Joost DeJongh, Teun Post… in Journal of Pharmacokinetics and Pharmacody… (2006)

  2. No Access

    Article

    A Human Physiologically-Based Model for Glycyrrhzic Acid, A Compound Subject to Presystemic Metabolism and Enterohepatic Cycling

    Purpose. To analyze the role of the kinetics of glycyrrhizic acid (GD) in its toxicity. A physiologically-based pharmacokinetic (PBPK) model that has been developed for humans.

    Bart Ploeger, Tjeert Mensinga, Adriënne Sips, Jan Meulenbelt… in Pharmaceutical Research (2000)