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6 Result(s)

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  1. No Access

    Article

    Glucose-Based Mesoporous Carbon Nanospheres as Functional Carriers for Oral Delivery of Amphiphobic Raloxifene: Insights into the Bioavailability Enhancement and Lymphatic Transport

    Oral therapy with raloxifene (RXF), an amphiphobic drug for remedy of the postmenopausal osteoporosis and estrogen-dependent breast cancer, is less effective due to its poor bioavailability (2% or so). This wo...

    Yanghuan Ye, Tianpeng Zhang, Wan Li, Hua Sun, Danyi Lu… in Pharmaceutical Research (2016)

  2. No Access

    Article

    A New Strategy to Rapidly Evaluate Kinetics of Glucuronide Efflux by Breast Cancer Resistance Protein (BCRP/ABCG2)

    The efflux transporter breast cancer resistance protein (BCRP/ABCG2) plays an important role in excretion of anionic drugs and metabolites including glucuronides in humans.

    Baojian Wu, Wen Jiang, Taijun Yin, Song Gao, Ming Hu in Pharmaceutical Research (2012)

  3. No Access

    Article

    Accurate Prediction of Glucuronidation of Structurally Diverse Phenolics by Human UGT1A9 Using Combined Experimental and In Silico Approaches

    Catalytic selectivity of human UGT1A9, an important membrane-bound enzyme catalyzing glucuronidation of xenobiotics, was determined experimentally using 145 phenolics and analyzed by 3D-QSAR methods.

    Baojian Wu, **aoqiang Wang, Shuxing Zhang, Ming Hu in Pharmaceutical Research (2012)

  4. No Access

    Article

    Magnetic tunability of fiber optical parametric oscillators with optical clock extraction

    A 10 Gb/s all-optical clock extraction based on magnetically controllable fiber optical parametric oscillator (MC-FOPO) is demonstrated. The operation properties of the magnetic control unit, composed of a sol...

    Tianzhi Le, Baojian Wu, Feng Wen, Kun Qiu in Frontiers of Optoelectronics in China (2011)

  5. No Access

    Article

    Regioselective Glucuronidation of Flavonols by Six Human UGT1A Isoforms

    Glucuronidation is a major barrier to flavonoid bioavailability; understanding its regiospecificity and reaction kinetics would greatly enhance our ability to model and predict flavonoid disposition. We aimed ...

    Baojian Wu, Beibei Xu, Ming Hu in Pharmaceutical Research (2011)

  6. No Access

    Article

    Simulation model of magneto-optic fiber Bragg gratings and its applications in Sagnac interferometers

    According to the symmetry of transmission matrix for non-uniform magneto-optic fiber Bragg gratings (MFBGs), the simulation model of the non-uniform MFBGs with bidirectional injection of light has been present...

    Shijuan Wu, Baojian Wu, Kun Qiu, Chongzhen Li in Frontiers of Optoelectronics in China (2010)