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  1. Article

    Nanosuspensions Containing Oridonin/HP-β-Cyclodextrin Inclusion Complexes for Oral Bioavailability Enhancement via Improved Dissolution and Permeability

    Chemotherapy via oral route of anticancer drugs offers much convenience and compliance to patients. However, oral chemotherapy has been challenged by limited absorption due to poor drug solubility and intestin...

    **ngwang Zhang, Tianpeng Zhang, Yali Lan, Baojian Wu, Zhihai Shi in AAPS PharmSciTech (2016)

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    Article

    Glucose-Based Mesoporous Carbon Nanospheres as Functional Carriers for Oral Delivery of Amphiphobic Raloxifene: Insights into the Bioavailability Enhancement and Lymphatic Transport

    Oral therapy with raloxifene (RXF), an amphiphobic drug for remedy of the postmenopausal osteoporosis and estrogen-dependent breast cancer, is less effective due to its poor bioavailability (2% or so). This wo...

    Yanghuan Ye, Tianpeng Zhang, Wan Li, Hua Sun, Danyi Lu… in Pharmaceutical Research (2016)

  3. Article

    Erratum to: Regioselective Glucuronidation of Andrographolide and Its Major Derivatives: Metabolite Identification, Isozyme Contribution, and Species Differences

    **angge Tian, Sicheng Liang, Chao Wang, Baojian Wu, Guangbo Ge, Sa Deng… in The AAPS Journal (2015)

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    Regioselective Glucuronidation of Andrographolide and Its Major Derivatives: Metabolite Identification, Isozyme Contribution, and Species Differences

    Andrographolide (AND) and two of its derivatives, deoxyandrographolide (DEO) and dehydroandrographolide (DEH), are widely used in clinical practice as anti-inflammatory agents. However, UDP-glucuronosyltransfe...

    **angge Tian, Sicheng Liang, Chao Wang, Baojian Wu, Guangbo Ge, Sa Deng… in The AAPS Journal (2015)

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    A New Strategy to Rapidly Evaluate Kinetics of Glucuronide Efflux by Breast Cancer Resistance Protein (BCRP/ABCG2)

    The efflux transporter breast cancer resistance protein (BCRP/ABCG2) plays an important role in excretion of anionic drugs and metabolites including glucuronides in humans.

    Baojian Wu, Wen Jiang, Taijun Yin, Song Gao, Ming Hu in Pharmaceutical Research (2012)

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    Article

    Accurate Prediction of Glucuronidation of Structurally Diverse Phenolics by Human UGT1A9 Using Combined Experimental and In Silico Approaches

    Catalytic selectivity of human UGT1A9, an important membrane-bound enzyme catalyzing glucuronidation of xenobiotics, was determined experimentally using 145 phenolics and analyzed by 3D-QSAR methods.

    Baojian Wu, **aoqiang Wang, Shuxing Zhang, Ming Hu in Pharmaceutical Research (2012)

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    Article

    Regioselective Glucuronidation of Flavonols by Six Human UGT1A Isoforms

    Glucuronidation is a major barrier to flavonoid bioavailability; understanding its regiospecificity and reaction kinetics would greatly enhance our ability to model and predict flavonoid disposition. We aimed ...

    Baojian Wu, Beibei Xu, Ming Hu in Pharmaceutical Research (2011)