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Article
Trends in confinement-induced cell migration and multi-omics analysis
Cell migration is an essential manner of different cell lines that are involved in embryological development, immune responses, tumorigenesis, and metastasis in vivo. Physical confinement derived from crowded ...
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Article
Calcium-sensing receptor and NF-κB pathways in TN breast cancer contribute to cancer-induced cardiomyocyte damage via activating neutrophil extracellular traps formation
Cardiovascular disorders are commonly prevalent in cancer patients, yet the mechanistic link between them remains poorly understood. Because neutrophil extracellular traps (NETs) have implications not just in ...
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Article
A review on CRISPR/Cas: a versatile tool for cancer screening, diagnosis, and clinic treatment
Cancer is one of the leading causes of death worldwide and it has the trend of increase incidence. However, in the past decades, as quickly developed new technologies and modified old techniques for cancer scr...
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Article
The resilient cotton plant: uncovering the effects of stresses on secondary metabolomics and its underlying molecular mechanisms
Cotton is an important fiber crop cultivated around the world under diverse climate conditions and generates billions of dollars in annual revenue globally. Biotic and abiotic stresses have caused reduction in...
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Article
Insights to Gossypium defense response against Verticillium dahliae: the Cotton Cancer
The soil-borne pathogen Verticillium dahliae, also referred as “The Cotton Cancer,” is responsible for causing Verticillium wilt in cotton crops, a destructive disease with a global impact. To infect cotton plant...
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Article
Associations Between the Lead Level in Maternal Blood and Umbilical Cord Blood and Congenital Heart Diseases in Offspring
The incidence of congenital heart diseases (CHDs) shows an increasing trend and results in large health burdens in China. However, there have been inconsistent results of the relationship between lead (Pb) lev...
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Article
RefFinder: a web-based tool for comprehensively analyzing and identifying reference genes
Although many genes may serve as reference genes, they may cause different expression patterns by selecting different reference genes because no single gene is expressed consistently in all tested tissues of a...
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Article
Genome Editing
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Article
Retraction Note to: A Novel Method for the Prevention and Treatment of Small‑for‑Size Syndrome in Liver Transplantation
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Article
The landscape of genome sequencing and assembling in plants
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Article
New vision on the new era of genome study
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Protocol
QuickIsoSeq for Isoform Quantification in Large-Scale RNA Sequencing
RNA-sequencing (RNA-seq) is a powerful technology for transcriptome profiling. While most RNA-seq projects focus on gene-level quantification and analysis, there is growing evidence that most mammalian genes a...
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Article
Open AccessEngineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration
Long-lived plasma cells (LLPCs) are robust specialized antibody-secreting cells that mainly stay in the bone marrow and can persist a lifetime. As they can be generated by inducing the differentiation of B-lym...
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Article
RETRACTED ARTICLE: A Novel Method for the Prevention and Treatment of Small-for-Size Syndrome in Liver Transplantation
Currently there is no consensus on the optimal management of small-for-size syndrome following liver transplantation. Here we describe a technique to alleviate portal hypertension and improve the hepatocyte re...
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Article
CRISPR/Cas9 genome editing shows the important role of AZC_2928 gene in nitrogen-fixing bacteria of plants
AZC_2928 gene (GenBank accession no. BAF88926.1) of Azorhizobium caulinodans ORS571 has sequence homology to 2,3-aminomutases. However, its function is unknown. In this study, we are for the first time to knock o...
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Article
MicroRNAs in model and complex organisms
Non-coding RNAs such as microRNAs (miRNAs) are very tiny ribonucleotides having an essential role in gene regulation at both post-transcriptional and translational levels. They are very conserved and expressed...
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Article
Migration of endophytic diazotroph Azorhizobium caulinodans ORS571 inside wheat (Triticum aestivum L) and its effect on microRNAs
Azorhizobium caulinodans ORS571, a novel rhizobium, forms endosymbionts with its nature host Sesbania rostrata, a semi-aquatic leguminous tree. Recent studies showed that A. caulinodans O...
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Article
Open AccessRBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes
Development of alternatively activated (M2) macrophage phenotypes is a complex process that is coordinately regulated by a plethora of pathways and factors. Here, we report that RBP-J, a DNA-binding protein th...
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Article
Identification and characterization of microRNAs in the plant parasitic root-knot nematode Meloidogyne incognita using deep sequencing
The root-knot nematode Meloidogyne incognita is among the most damaging plant-parasitic pests of several crops including cotton (Gossypium hirsutum) and tomato (Lycopersicon escultentum). Recently, a genome has b...
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Article
Selection and validation of reliable reference genes in Gossypium raimondii
To identify reliable reference genes for gene expression analysis in Gossypium raimondii.