Environmental Toxicology and Toxicogenomics
Principles, Methods, and Applications
Page
%P
38 Result(s)
within
Baohong **
Biomedicine
-
Article
Open AccessThe immunotoxin targeting PRLR increases tamoxifen sensitivity and enhances the efficacy of chemotherapy in breast cancer
Though tamoxifen achieves success in treating estrogen receptor α (ERα)-positive breast cancer, the followed development of tamoxifen resistance is a common challenge in clinic. Signals downstream of prolactin...
-
Article
Open AccessImpact of NDUFAF6 on breast cancer prognosis: linking mitochondrial regulation to immune response and PD-L1 expression
Breast cancer is a major global health concern, and there is a continuous search for novel biomarkers to predict its prognosis. The mitochondrial protein NDUFAF6, previously studied in liver cancer, is now bei...
-
Article
Open AccessPan cancer characterization of genes whose expression has been associated with LINE-1 antisense promoter activity
Long interspersed nuclear element-1 (LINE-1 or L1) comprises 17% of the human genome. As the only autonomous and active retrotransposons, L1 may take part in cancer initiation and progression in some ways. The...
-
Article
The interaction between first-episode drug-naïve schizophrenia and age based on gray matter volume and its molecular analysis: a multimodal magnetic resonance imaging study
Schizophrenia is a neurodevelopmental disorder characterized by progressive and widespread gray matter (GM) atrophy. Studies have shown that normal brain development has an impact on schizophrenia-induced GM a...
-
Article
Open AccessIntegrated single-cell transcriptomics of cerebrospinal fluid cells in treatment-naïve multiple sclerosis
Multiple sclerosis (MS) is a chronic and often disabling autoimmune disease of the central nervous system (CNS). Cerebrospinal fluid (CSF) surrounds and protects the CNS. Analysis of CSF can aid the diagnosis ...
-
Article
Open AccessThe reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China
Assessment of immune function is of key importance in recognition of disease or healthy status, which still faces challenge in clinical practice. We conducted a 10-center study to investigate lymphocyte parame...
-
Article
Catalpol Ameliorates Neurotoxicity in N2a/APP695swe Cells and APP/PS1 Transgenic Mice
Alzheimer’s disease (AD) causes progressive decline of memory and cognitive deficits. Because of its complicated pathogenesis, the prevention and therapy of AD remain an enormous challenge. It has been reporte...
-
Article
Open AccessEimeria falciformis secretes extracellular vesicles to modulate proinflammatory response during interaction with mouse intestinal epithelial cells
Protozoan parasite secretions can be triggered by various modified media and diverse physicochemical stressors. Equally, host-parasite interactions are known to co-opt the exchange and secretion of soluble bio...
-
Article
Paeonol triggers apoptosis in HeLa cervical cancer cells: the role of mitochondria-related caspase pathway
Paeonol is a biologically active component purified from the root bark of Cortex Moutan that exerts pharmacological effects on the cervical cancer. In this study, we aim to evaluate the anti-cervical cancer ca...
-
Article
Saikosaponin-D Mitigates Oxidation in SH-SY5Y Cells Stimulated by Glutamate Through Activation of Nrf2 Pathway: Involvement of PI3K
Alzheimer’s disease (AD) is a typical neurodegenerative disease. Well-established studies have shown an elevated level of ROS (reactive oxygen species) that induces oxidative stress in AD. Saikosaponin-D exhib...
-
Article
Correction to: Protective effects of crocin against endogenous Aβ‑induced neurotoxicity in N2a/APP695swe cells
-
Article
Protective effects of crocin against endogenous Aβ-induced neurotoxicity in N2a/APP695swe cells
Alzheimer’s disease (AD) is a most common neurodegenerative disorder worldwide. Because of its complex pathogenesis, the prevention and therapies of AD still are a severe challenge. Evidence suggested that cro...
-
Article
Three paralogous clusters of the miR-17~92 family of microRNAs restrain IL-12-mediated immune defense
MicroRNAs (miRNAs) have been widely implicated in immune regulation, but evidence for the coordinated function of paralogous miRNA clusters remains scarce. Here, by using genetically modified mice with individ...
-
Article
CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvement
Since it was first recognized in bacteria and archaea as a mechanism for innate viral immunity in the early 2010s, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (...
-
Protocol
Impact of Nanoparticles on Plant Growth, Development, and Biomass
Nanoparticles are an extensive class of naturally occurred or man-made objects; it has been widely using in our daily life. As increasing usage, nanoparticles are also released into the environment and are bec...
-
Protocol
Biochemical and Physiological Toxicity of Nanoparticles in Plant
As increasing application of nanoparticles, nanoparticles have been becoming a new emerging environmental pollution that attracts a lot of attention from the scientific community and also regulatory agents. In...
-
Protocol
Identification of Stable Reference Genes for Toxicogenomic and Gene Expression Analysis
Gene expression analysis has been becoming a popular method for studying gene function and response to different environmental stresses, including toxin/pollution exposure. Selection of a suitable reference ge...
-
Book
-
Article
Open AccessNeuroprotective effect of astrocyte-derived IL-33 in neonatal hypoxic-ischemic brain injury
Interleukin-33 (IL-33) is a well-recognized pleiotropic cytokine which plays crucial roles in immune regulation and inflammatory responses. Recent studies suggest that IL-33 and its receptor ST2 are involved i...
-
Article
Open AccessA novel bispecific antibody targeting CD3 and prolactin receptor (PRLR) against PRLR-expression breast cancer
Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown ...
