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  1. No Access

    Article

    In vitro generation of mature, naive antigen-specific CD8+ T cells with a single T-cell receptor by agonist selection

    Peripheral blood T cells transduced with a tumor-specific T-cell receptor (TCR) face problems of auto-reactivity and lack of efficacy caused by cross-pairing of exogenous and endogenous TCR chains, as well as ...

    S Snauwaert, G Verstichel, S Bonte, G Goetgeluk, S Vanhee, Y Van Caeneghem… in Leukemia (2014)

  2. No Access

    Article

    Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway

    In wild-type mice, T-cell receptor (TCR) γδ+ cells differentiate along a CD4 CD8 double-negative (DN) pathway whereas TCRαβ+ cells differentiate along the double-positive (DP) pathway. In the human postnatal thym...

    S Van Coppernolle, S Vanhee, G Verstichel, S Snauwaert, A van der Spek… in Leukemia (2012)