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Article
Open AccessSiramesine triggers cell death through destabilisation of mitochondria, but not lysosomes
A sigma-2 receptor agonist siramesine has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo. However, its mechanism of action is still poorly understood. We show...
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Open AccessMAGUKs, scaffolding proteins at cell junctions, are substrates of different proteases during apoptosis
A major feature of apoptotic cell death is gross structural changes, one of which is the loss of cell–cell contacts. The caspases, executioners of apoptosis, were shown to cleave several proteins involved in t...
