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within B. Milojkovic Kerklaan Remove this filter Medicine & Public Health Remove this filter

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  1. No Access

    Article

    A phase I, dose escalation, pharmacodynamic, pharmacokinetic, and food-effect study of α2 integrin inhibitor E7820 in patients with advanced solid tumors

    Introduction E7820 is an orally administered sulfonamide that inhibits alfa-2-integrin mRNA expression. Pre-clinically E7820 showed tumor anti-angiogenic effects in various tumor cell lin...

    B. Milojkovic Kerklaan, S. Slater, M. Flynn, A. Greystoke… in Investigational New Drugs (2016)

  2. No Access

    Article

    Strategies to target drugs to gliomas and CNS metastases of solid tumors

    The treatment for central nervous system metastases of solid tumors and gliomas is limited as the blood–brain barrier (BBB) is an obstacle to systemic therapy. Here, we review the physiochemical properties of ...

    B. Milojkovic Kerklaan, O. van Tellingen, A. D. R. Huitema… in Journal of Neurology (2016)