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  1. No Access

    Chapter

    Immunogenicity of Lipopolysaccharide Derived from Brucella abortus: Potential as a Carrier in Development of Vaccines for AIDS

    In view of its unique ability to stimulate human B cells, we have considered using Brucella abortus (BA) as a carrier for human vaccines. Recently we showed that HIV-1 coupled to BA, but not unconjugated HIV-1...

    J. Goldstein, D. Hernandez, C. Frasch… in Immunobiology of Proteins and Peptides VI (1991)

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    Chapter

    Design of Vaccines for the Induction of Antibody Responses in Th-Cell Deficient Individuals

    Development of a vaccine to protect against infection with HIV-1 or to enhance antiviral immunity after HIV-1 has established itself in the host, is a major challenge to researchers. The virus has evolved many...

    B. Golding, J. Inman, H. Golding in Vaccines (1995)

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    Chapter

    Strategies for the Stimulation of Th Cell Subsets

    Our understanding of the role of T cell subsets and cytokines in protective immunity is based on evidence that CD4+ T cells can be separated into subsets on the basis of the profile of cytokines they produce. ...

    H. Golding, M. B. Zaitseva, C. Lapham, B. Golding in Vaccines (1995)

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    Chapter

    Induction of IL-12 Secretion and Enhanced Surface Expression of B7.1/B7.2 and ICAM-1 in Human Monocytes Activated by the Vaccine Carrier Brucella Abortus: Correlation with in Vivo Generation of Cellular Immune Responses

    It is well established that two cytokines, IFN-γ and IL-4, play an important role in the differentiation of Th0/Tc0 cells into effector types Th1/Tc1 or Th2/Tc2 cells during the initial phase of the immune res...

    H. Golding, M. B. Zaitseva, C. K. Lapham, B. Golding in Vaccine Design (1997)