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  1. No Access

    Chapter

    Immunogenicity of Lipopolysaccharide Derived from Brucella abortus: Potential as a Carrier in Development of Vaccines for AIDS

    In view of its unique ability to stimulate human B cells, we have considered using Brucella abortus (BA) as a carrier for human vaccines. Recently we showed that HIV-1 coupled to BA, but not unconjugated HIV-1...

    J. Goldstein, D. Hernandez, C. Frasch… in Immunobiology of Proteins and Peptides VI (1991)

  2. Article

    The prospects for polymorphisms shared between species

    Recent molecular evidence has shown that many MHC polymorphisms are not only shared between species but are in fact identical at the molecular level. Species that share these polymorphisms may be very distantl...

    B Golding in Heredity (1992)

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  3. No Access

    Chapter

    Design of Vaccines for the Induction of Antibody Responses in Th-Cell Deficient Individuals

    Development of a vaccine to protect against infection with HIV-1 or to enhance antiviral immunity after HIV-1 has established itself in the host, is a major challenge to researchers. The virus has evolved many...

    B. Golding, J. Inman, H. Golding in Vaccines (1995)

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    Chapter

    Strategies for the Stimulation of Th Cell Subsets

    Our understanding of the role of T cell subsets and cytokines in protective immunity is based on evidence that CD4+ T cells can be separated into subsets on the basis of the profile of cytokines they produce. ...

    H. Golding, M. B. Zaitseva, C. Lapham, B. Golding in Vaccines (1995)

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    Article

    Partial characterization of the genome of nine animal caliciviruses

    Caliciviruses (CVs) include at least 42 distinct serotypes. Seventeen CV serotypes have been isolated from marine sources and are called San Miguel sea lion caliciviruses (SMSVs). CVs also have been isolated f...

    D. O. Matson, T. Berke, M. B. Dinulos, E. Poet, W.-M. Zhong… in Archives of Virology (1996)

  6. No Access

    Chapter

    Induction of IL-12 Secretion and Enhanced Surface Expression of B7.1/B7.2 and ICAM-1 in Human Monocytes Activated by the Vaccine Carrier Brucella Abortus: Correlation with in Vivo Generation of Cellular Immune Responses

    It is well established that two cytokines, IFN-γ and IL-4, play an important role in the differentiation of Th0/Tc0 cells into effector types Th1/Tc1 or Th2/Tc2 cells during the initial phase of the immune res...

    H. Golding, M. B. Zaitseva, C. K. Lapham, B. Golding in Vaccine Design (1997)