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  1. Article

    Open Access

    Increased epicardial adipose tissue is associated with left atrial mechanical dysfunction in patients with heart failure with mildly reduced and preserved ejection fraction

    Heart failure (HF) with mildly reduced and preserved ejection fraction (HFmrEF/HFpEF) is often accompanied by atrial dysfunction. It has been suggested that specific ectopic fat depots, such as epicardial adip...

    M. Lobeek, T. M. Gorter, B. D. Westenbrink in Clinical Research in Cardiology (2024)

  2. Article

    Open Access

    Rationale and design of the PHOspholamban RElated CArdiomyopathy intervention STudy (i-PHORECAST)

    The p.Arg14del (c.40_42delAGA) phospholamban (PLN) pathogenic variant is a founder mutation that causes dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM). Carriers are at increased risk of m...

    W. P. te Rijdt, E. T. Hoorntje, R. de Brouwer, A. Oomen in Netherlands Heart Journal (2022)

  3. Article

    Open Access

    Improvement in left ventricular ejection fraction after pharmacological up-titration in new-onset heart failure with reduced ejection fraction

    Recent studies have reported suboptimal up-titration of heart failure (HF) therapies in patients with heart failure and a reduced ejection fraction (HFrEF). Here, we report on the achieved doses after nurse-le...

    J. F. Nauta, B. T. Santema, M. H. L. van der Wal, A. Koops in Netherlands Heart Journal (2021)

  4. Article

    Open Access

    Young@Heart: empowering the next generation of cardiovascular researchers

    In recognition of the increasing health burden of cardiovascular disease, the Dutch CardioVascular Alliance (DCVA) was founded with the ambition to lower the cardiovascular disease burden by 25% in 2030. To ac...

    M. F. Hoes, A. S. J. M. te Riele, M. M. Gladka in Netherlands Heart Journal (2020)