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Article
Open AccessA novel pathway of levodopa metabolism by commensal Bifidobacteria
The gold-standard treatment for Parkinson’s disease is levodopa (L-DOPA), which is taken orally and absorbed intestinally. L-DOPA must reach the brain intact to exert its clinical effect; peripheral metabolism...
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Article
Open AccessCross-feeding between intestinal pathobionts promotes their overgrowth during undernutrition
Child undernutrition is a global health issue associated with a high burden of infectious disease. Undernourished children display an overabundance of intestinal pathogens and pathobionts, and these bacteria i...
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Chapter and Conference Paper
Advances in the Study of Blastocystis spp. in Mexico: Prevalence, Genetic Diversity, Clinical Association and Their Possible Role in the Human Intestine
Blastocystis spp. has a worldwide distribution, and it has been associated with gastrointestinal symptomatology; however, its role in health or disease remains unclear. Subtype 3 is the most frequently reported s...
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Article
Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body
The authors report the structure of the assembled membrane spanning ring forming proteins of the Salmonella Typhimurium injectisome basal body, including the first atomic structure of a member of the secretin fam...
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Article
Reduced in vitro functional activity of human NRAMP1 (SLC11A1) allele that predisposes to increased risk of pediatric tuberculosis disease
Polymorphic variants within the human natural resistance-associated macrophage protein-1 (NRAMP1, also known as SLC11A1) gene have been shown to impact on susceptibility to tuberculosis in different human populat...
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Chapter
Bacterial Virulence Strategies That Utilize Rho GTPases
The ability to modify central host cellular functions is a major advantage to many bacterial pathogens that use such strategies as part of their virulence mechanisms. Small GTPases, including Rho GTPases, make...
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Article
Enteropathogenic Escherichia coli: a pathogen that inserts its own receptor into host cells
Enteropathogenic Escherichia coli (EPEC) is a major cause of infant diarrhea, killing hundreds of thousands of children per year worldwide. Intimate attachment to the host cell leading to the formation of actin-...
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Chapter
Bacterial Epithelial Cell Cross Talk
The ability to bind to epithelial cells is an important determinant of virulence for many pathogenic bacteria. The interaction of enteropathogens with host cells of the intestinal epithelia can lead to either ...
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Chapter
Molecular and Cellular Mechanisms of Salmonella Pathogenesis
“Salmonellae are among the most resourceful and successful of human pathogens, and as such have long beguiled microbiologists, epidemiologists, and clinicians” (RUBIN et al. 1977) . And they continue to do so! Ho...