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Article
Cooperation of BRAFF595L and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling
Activating BRAF mutations, in particular V600E/K, drive many cancers and are considered mutually exclusive with mutant RAS, whereas inactivating BRAF mutations in the D594F595G596 motif cooperate with RAS via par...
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Article
Open AccessInvestigation of manic and euthymic episodes identifies state- and trait-specific gene expression and STAB1 as a new candidate gene for bipolar disorder
Bipolar disorder (BD) is a highly heritable psychiatric disease characterized by recurrent episodes of mania and depression. To identify new BD genes and pathways, the present study employed a three-step appro...
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Article
Molekularpathologie von Sarkomen
Zur präzisen Diagnostik von Sarkomen und Behandlung in spezialisierten Zentren hat sich mit Förderung durch die Deutsche Krebshilfe (DKH) der Sarkomforschungsverbund KoSar (Kompetenznetz Sarkome) gebildet. Die...
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Article
Integrated genomic profiling identifies two distinct molecular subtypes with divergent outcome in neuroblastoma with loss of chromosome 11q
Imbalances in chromosome 11q occur in approximately 30% of primary neuroblastoma and are associated with poor outcome. It has been suggested that 11q loss constitutes a distinct clinico-genetic neuroblastoma s...
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Article
The hematopoietic stem cell in chronic phase CML is characterized by a transcriptional profile resembling normal myeloid progenitor cells and reflecting loss of quiescence
We found that composition of cell subsets within the CD34+ cell population is markedly altered in chronic phase (CP) chronic myeloid leukemia (CML). Specifically, proportions and absolute cell counts of common...
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Article
Expression of the tumour suppressor gene CADM1 is associated with favourable outcome and inhibits cell survival in neuroblastoma
Cell adhesion molecule 1 (CADM1) is a putative tumour suppressor gene, which is downregulated in many solid tumours. In neuroblastoma, loss of CADM1 expression has recently been found in disseminated tumours with...
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Chapter and Conference Paper
Systematische Untersuchung von Kombinationswirkungen der HHV-8-Gene auf die NF-κB-Aktivierung
Activation of nuclear factor-kappa B (NF-κB), a key regulatory molecule in inflammation, is essential for survival of Human Herpesvirus (HHV)-8-infected cells. Using reverse transfection cell arrays (RTCA) as ...
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Article
Molecular signature of CD34+ hematopoietic stem and progenitor cells of patients with CML in chronic phase
In this study, we provide a molecular signature of highly enriched CD34+ cells from bone marrow of untreated patients with chronic myelogenous leukemia (CML) in chronic phase in comparison with normal CD34+ ce...
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Article
Gene expression signature of primary imatinib-resistant chronic myeloid leukemia patients
Although the selective tyrosine kinase inhibitor imatinib is successfully used in the treatment of chronic myeloid leukemia (CML), inherent mechanisms confer primary resistance to leukemic patients. In order t...
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Article
Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis
Despite recent success in the treatment of early-stage disease, blastic phase (BP) of chronic myeloid leukemia (CML) that is characterized by rapid expansion of therapy-refractory and differentiation-arrested ...
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Article
Gene expression profiling of Philadelphia chromosome (Ph)-negative CD34+ hematopoietic stem and progenitor cells of patients with Ph-positive CML in major molecular remission during therapy with imatinib