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  1. No Access

    Article

    Cooperation of BRAFF595L and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling

    Activating BRAF mutations, in particular V600E/K, drive many cancers and are considered mutually exclusive with mutant RAS, whereas inactivating BRAF mutations in the D594F595G596 motif cooperate with RAS via par...

    M Kordes, M Röring, C Heining, S Braun, B Hutter, D Richter, C Geörg, C Scholl… in Leukemia (2016)

  2. No Access

    Article

    The hematopoietic stem cell in chronic phase CML is characterized by a transcriptional profile resembling normal myeloid progenitor cells and reflecting loss of quiescence

    We found that composition of cell subsets within the CD34+ cell population is markedly altered in chronic phase (CP) chronic myeloid leukemia (CML). Specifically, proportions and absolute cell counts of common...

    I Bruns, A Czibere, J C Fischer, F Roels, R-P Cadeddu, S Buest, D Bruennert… in Leukemia (2009)

  3. No Access

    Article

    Molecular signature of CD34+ hematopoietic stem and progenitor cells of patients with CML in chronic phase

    In this study, we provide a molecular signature of highly enriched CD34+ cells from bone marrow of untreated patients with chronic myelogenous leukemia (CML) in chronic phase in comparison with normal CD34+ ce...

    E Diaz-Blanco, I Bruns, F Neumann, J C Fischer, T Graef, M Rosskopf, B Brors… in Leukemia (2007)

  4. No Access

    Article

    Gene expression signature of primary imatinib-resistant chronic myeloid leukemia patients

    Although the selective tyrosine kinase inhibitor imatinib is successfully used in the treatment of chronic myeloid leukemia (CML), inherent mechanisms confer primary resistance to leukemic patients. In order t...

    O Frank, B Brors, A Fabarius, L Li, M Haak, S Merk, U Schwindel, C Zheng… in Leukemia (2006)

  5. No Access

    Article

    Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis

    Despite recent success in the treatment of early-stage disease, blastic phase (BP) of chronic myeloid leukemia (CML) that is characterized by rapid expansion of therapy-refractory and differentiation-arrested ...

    C Zheng, L Li, M Haak, B Brors, O Frank, M Giehl, A Fabarius, M Schatz… in Leukemia (2006)

  6. No Access

    Article

    Gene expression profiling of Philadelphia chromosome (Ph)-negative CD34+ hematopoietic stem and progenitor cells of patients with Ph-positive CML in major molecular remission during therapy with imatinib

    F Neumann, N Teutsch, S Kliszewski, S Bork, U Steidl, B Brors, N Schimkus… in Leukemia (2005)