39,306 Result(s)
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Science, Humanities and Social Sciences, multidisciplinary
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Article
On Direct Metal Laser Sintering of Functionally Graded Material with Virgin and Mixed Powder
In the recent past, several studies were reported on meta-structure-based direct metal laser sintering (DMLS) of functionally graded materials (FGM) using virgin/recycled metallic powders. But hitherto little ...
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Exploring Microstructural, Textural, and Mechanical Properties in Bulk-Area Stir Zone Fabrication Through Overlap** Friction Stir Processing with Water Cooling
In this study, a bulk-area stirring zone (BSZ) was generated within the Al–Mg–Si alloy using friction stir processing with a combination of pin overlap** and water cooling. Detailed examinations were conduct...
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Thermal and Energy Transport Prediction in Non-Newtonian Biomagnetic Hybrid Nanofluids using Gaussian Process Regression
Hybrid nanofluids are a type of nanofluid that is created by combining two different types of nanoparticles with a traditional fluid. These nanofluids have unique physicochemical properties that make them more...
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Open AccessFlhE functions as a chaperone to prevent formation of periplasmic flagella in Gram-negative bacteria
The bacterial flagellum, which facilitates motility, is composed of ~20 structural proteins organized into a long extracellular filament connected to a cytoplasmic rotor-stator complex via a periplasmic rod. F...
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EV Fleet Energy Management Strategy For Smart Microgrids Considering Multiple Objectives: Techno-Economic Perspective
Rapid advancements in battery technologies led to dramatic growth in adoption of electric vehicles (EVs) all over the world. On the other hand, ever-increasing renewable energy sources (RES) in microgrids (MGs...
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Open AccessUncertainty quantification for probabilistic machine learning in earth observation using conformal prediction
Machine learning is increasingly applied to Earth Observation (EO) data to obtain datasets that contribute towards international accords. However, these datasets contain inherent uncertainty that needs to be q...
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Open AccessIn vivo turnover and biodistribution of soluble AXL: implications for biomarker development
Soluble biomarkers are paramount to personalized medicine. However, the in vivo turnover and biodistribution of soluble proteins is seldom characterized. The cleaved extracellular domain of the AXL receptor (s...
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Open AccessG0-PCC-FISH derived multi-parametric biodosimetry methodology for accidental high dose and partial body exposures
High dose radiation exposures are rare. However, medical management of such incidents is crucial due to mortality and tissue injury risks. Rapid radiation biodosimetry of high dose accidental exposures is high...
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Open AccessInsidious racism and institutional constraints: evidence from national and local case studies in the United States
In recent years, researchers have become increasingly interested in educational and institutional strategies to limit or eradicate contemporary forms of racism in the United States. They have generally accepte...
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Open AccessGenetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center
The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington University in St. Louis has pioneered and led worldwide seminal studies that have expanded our clinical, social, pathological, and molec...
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Open AccessAdeno-associated virus delivered CXCL9 sensitizes glioblastoma to anti-PD-1 immune checkpoint blockade
There are numerous mechanisms by which glioblastoma cells evade immunological detection, underscoring the need for strategic combinatorial treatments to achieve appreciable therapeutic effects. However, develo...
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Open AccessTargeting soluble amyloid-beta oligomers with a novel nanobody
The classical amyloid cascade hypothesis postulates that the aggregation of amyloid plaques and the accumulation of intracellular hyperphosphorylated Tau tangles, together, lead to profound neuronal death. How...
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Open AccessUbiquitous purine sensor modulates diverse signal transduction pathways in bacteria
Purines and their derivatives control intracellular energy homeostasis and nucleotide synthesis, and act as signaling molecules. Here, we combine structural and sequence information to define a purine-binding ...
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Open AccessMolecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer
To inform clinical trial design and real-world precision pediatric oncology practice, we classified diagnoses, assessed the landscape of mutations, and identified genomic variants matching trials in a large un...
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Open AccessAuthor Correction: dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe
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Open AccessEnhanced SOC estimation of lithium ion batteries with RealTime data using machine learning algorithms
Accurately estimating Battery State of Charge (SOC) is essential for safe and optimal electric vehicle operation. This paper presents a comparative assessment of multiple machine learning regression algorithms...
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Open AccessEarly mutational signatures and transmissibility of SARS-CoV-2 Gamma and Lambda variants in Chile
Genomic surveillance (GS) programmes were crucial in identifying and quantifying the mutating patterns of SARS-CoV-2 during the COVID-19 pandemic. In this work, we develop a Bayesian framework to quantify the ...
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Open AccessTumor cell-directed STING agonist antibody-drug conjugates induce type III interferons and anti-tumor innate immune responses
Activating interferon responses with STING agonists (STINGa) is a current cancer immunotherapy strategy, and therapeutic modalities that enable tumor-targeted delivery via systemic administration could be bene...
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Open AccessUnderstanding global perspectives for the acceptance of community sanitation welfare schemes through a localised qualitative survey in Kho Nagorian, Jaipur, India
Community sanitation is a fundamental human right and need. Every year, as per the World Bank, total cost of providing sanitation services is estimated at around 114 billion USD per year. In India, Swachh Bhar...
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Open AccessA diverse proteome is present and enzymatically active in metabolite extracts
Metabolite extraction is the critical first-step in metabolomics experiments, where it is generally regarded to inactivate and remove proteins. Here, arising from efforts to improve extraction conditions for p...
