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Article
Neuregulins rescue PC12-ErbB-4 cells from cell death induced by β-amyloid peptide
Neuregulins (NRGs), which are highly expressed in the nervous system, bind and activate two receptor tyrosine kinases, ErbB-3 and ErbB-4. We previously showed that NRG mediates survival of PC12-ErbB-4 cells fr...
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Article
ErbB4 activation inhibits MPP+-induced cell death in PC12-ErbB4 cells
The neuroprotective effects of neuregulin (NRG), a polypeptide growth factor, on 1-methyl-4-phenylpyridinium ion (MPP+)-induced cell death and oxidative stress in PC12-ErbB4 cells were investigated. Treatment ...
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Article
The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA
Gene expression can be regulated post-transcriptionally through dynamic and reversible RNA modifications. A recent noteworthy example is N6-methyladenosine (m6A), which affects messenger RNA (mRNA) localization, ...
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Article
Open AccessFecal microbial characterization of hospitalized patients with suspected infectious diarrhea shows significant dysbiosis
Hospitalized patients are at increased risk for acquiring healthcare-associated infections (HAIs) and inadequate nutrition. The human intestinal microbiota plays vital functions in nutrient supply and protecti...
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Article
Open AccessRNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure
Adenosine deaminase acting on RNA 1 (ADAR1) is the master RNA editor, catalyzing the deamination of adenosine to inosine. RNA editing is vital for preventing abnormal activation of cytosolic nucleic acid sensi...
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Article
Open AccessDefining the Celiac Disease Transcriptome using Clinical Pathology Specimens Reveals Biologic Pathways and Supports Diagnosis
Celiac disease is provoked by gluten exposure, but the complete pathogenic process in the duodenum and the loss of tolerance to gluten is not well understood. We aimed to define the core celiac transcriptomic ...
