4 Result(s)

Article

ATP-dependent modulation of MgtE in Mg²⁺ homeostasis

Magnesium is an essential ion for numerous physiological processes. MgtE is a Mg²⁺ selective channel involved in the maintenance of intracellular Mg²⁺ homeostasis, whose gating is regulated by intracellular Mg²⁺ ...

Atsuhiro Tomita, Mingfeng Zhang, Fei **, Wenhui Zhuang… in Nature Communications (2017)

Article

Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility

Outer hair cell elecromotility, driven by prestin, is essential for mammalian cochlear amplification. Here, we report the cryo-EM structures of thermostabilized prestin (Pres^TS), complexed with chloride, sulfate,...

Haon Futamata, Masahiro Fukuda, Rie Umeda, Keitaro Yamashita… in Nature Communications (2022)

Article

Author Correction: Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility

Haon Futamata, Masahiro Fukuda, Rie Umeda, Keitaro Yamashita… in Nature Communications (2022)

Article

Class B1 GPCR activation by an intracellular agonist

G protein-coupled receptors (GPCRs) generally accommodate specific ligands in the orthosteric-binding pockets. Ligand binding triggers a receptor allosteric conformational change that leads to the activation o...

Kazuhiro Kobayashi, Kouki Kawakami, Tsukasa Kusakizako, Atsuhiro Tomita… in Nature (2023)