8 Result(s)
within
Asif Javed
Life Sciences
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Article
Open AccessMinimizing recombinations in consensus networks for phylogeographic studies
We address the problem of studying recombinational variations in (human) populations. In this paper, our focus is on one computational aspect of the general task: Given two networks G1 and G2, with both mutation ...
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Article
Open AccessA minimal descriptor of an ancestral recombinations graph
Ancestral Recombinations Graph (ARG) is a phylogenetic structure that encodes both duplication events, such as mutations, as well as genetic exchange events, such as recombinations: this captures the (genetic)...
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Article
Open AccessAn international effort towards develo** standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge
There is tremendous potential for genome sequencing to improve clinical diagnosis and care once it becomes routinely accessible, but this will require formalizing research methods into clinical best practices ...
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Phen-Gen: combining phenotype and genotype to analyze rare disorders
To find causative mutations in rare disorders, the Phen-Gen software combines disease symptoms and sequencing data with prior knowledge about the gene.
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Article
Isolation and 3D expansion of multipotent Sox9+ mouse lung progenitors
This paper describes methods for the 3D culture of mouse lung progenitor cells that can differentiate in vitro and in vivo along all epithelial lineages.
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Article
Soil arsenic but not rice arsenic increasing with arsenic in irrigation water in the Punjab plains of Pakistan
Irrigating rice with groundwater can lead to As accumulation in soil and rice grains. Matched sets of irrigation water, paddy soil, and rice grains were collected to assess the scale of the problem in the Punj...
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Article
Open AccessAdipose tissue-derived human mesenchymal stromal cells can better suppress complement lysis, engraft and inhibit acute graft-versus-host disease in mice
Acute graft-versus-host disease (aGvHD) is a life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT). Transplantation of immunosuppressive human mesenchymal stromal cells (hM...
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Article
Open AccessePRINT: exonuclease assisted map** of protein-RNA interactions
RNA-binding proteins (RBPs) regulate key aspects of RNA processing including alternative splicing, mRNA degradation and localization by physically binding RNA molecules. Current methods to map these interactio...
