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  1. Article

    Open Access

    An external pilot cluster randomised controlled trial of a theory-based intervention to improve appropriate polypharmacy in older people in primary care (PolyPrime)

    For older populations with multimorbidity, polypharmacy (use of multiple medications) is a standard practice. PolyPrime is a theory-based intervention developed to improve appropriate polypharmacy in older peo...

    Audrey Rankin, Ashleigh Gorman, Judith Cole in Pilot and Feasibility Studies (2022)

  2. Article

    Open Access

    An external pilot cluster randomised controlled trial of a theory-based intervention to improve appropriate polypharmacy in older people in primary care (PolyPrime): study protocol

    The use of multiple medications (polypharmacy) is a concern in older people (≥65 years) and is associated with negative health outcomes. For older populations with multimorbidity, polypharmacy is the reality a...

    Audrey Rankin, Cathal A. Cadogan, Heather E. Barry in Pilot and Feasibility Studies (2021)

  3. Article

    Open Access

    Early switch from intravenous to oral antibiotic therapy in patients with cancer who have low-risk neutropenic sepsis (the EASI-SWITCH trial): study protocol for a randomised controlled trial

    Neutropenic sepsis remains a common treatment complication for patients receiving systemic anti-cancer treatment. The UK National Institute for Health and Care Excellence have not recommended switching from em...

    Caroline Forde, Ronan McMullan, Mike Clarke, Richard H. Wilson, Ruth Plummer in Trials (2020)

  4. Article

    Open Access

    A 2 × 2 factorial, randomised, open-label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in adults with bronchiectasis: a protocol for the CLEAR clinical trial

    Current guidelines for the management of bronchiectasis (BE) highlight the lack of evidence to recommend mucoactive agents, such as hypertonic saline (HTS) and carbocisteine, to aid sputum removal as part of s...

    Judy Martina Bradley, Rohan Anand, Brenda O’Neill, Kathryn Ferguson, Mike Clarke in Trials (2019)

  5. Article

    Open Access

    Prevention of post-operative complications by using a HMG-CoA reductase inhibitor in patients undergoing one-lung ventilation for non-cardiac surgery: study protocol for a randomised controlled trial

    Postoperative pulmonary complications (PPC) and peri-operative myocardial infarction (MI) have a significant impact on the long-term mortality of surgical patients. Patients undergoing one-lung ventilation (OL...

    Murali Shyamsundar, Cecilia O’Kane, Gavin D. Perkins, Gavin Kennedy in Trials (2018)

  6. Article

    Open Access

    Assessment of the effect of addition of 24 hours of oral tranexamic acid post-operatively to a single intraoperative intravenous dose of tranexamic acid on calculated blood loss following primary hip and knee arthroplasty (TRAC-24): a study protocol for a randomised controlled trial

    While it is has been proven that tranexamic acid (TXA) reduces blood loss in primary total hip and knee arthroplasty (THA and TKA), there is little published evidence on the use of TXA beyond 3 h post-operativ...

    Janet Hill, Paul Magill, Alastair Dorman, Rosemary Hogg, Andrew Eggleton in Trials (2018)

  7. Article

    Open Access

    Evaluating early administration of the hydroxymethylglutaryl-CoA reductase inhibitor simvastatin in the prevention and treatment of delirium in critically ill ventilated patients (MoDUS trial): study protocol for a randomized controlled trial

    The incidence of delirium in ventilated patients is estimated at up to 82%, and it is associated with longer intensive care and hospital stays, and long-term cognitive impairment and mortality. The pathophysio...

    Annalisa Casarin, Daniel F McAuley, Timothy M Alce, **aobei Zhao, E Wesley Ely in Trials (2015)

  8. Article

    Open Access

    Effectiveness of a programme of exercise on physical function in survivors of critical illness following discharge from the ICU: study protocol for a randomised controlled trial (REVIVE)

    Following discharge home from the ICU, patients often suffer from reduced physical function, exercise capacity, health-related quality of life and social functioning. There is usually no support to address the...

    Brenda O'Neill, Kathryn McDowell, Judy Bradley, Bronagh Blackwood, Brian Mullan in Trials (2014)