6 Result(s)
within
Ashfaque A. Memon
Hematology
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Article
Open AccessMitochondria-DNA copy-number and incident venous thromboembolism among middle-aged women: a population-based cohort study
Venous thromboembolism (VTE) is the third most common cardiovascular disease. Low amount of mitochondrial DNA copy number (mtDNA-CN) has been associated with arterial cardiovascular disease (CVD) and reflects ...
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Article
Open AccessRisk prediction of recurrent venous thromboembolism: a multiple genetic risk model
A single genetic biomarker is unable to accurately predict the risk for venous thromboembolism (VTE) recurrence. We aimed to: (a) develop a multiple single nucleotide polymorphisms (SNPs) model to predict the ...
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Article
Open AccessPolymorphisms in PARK2 and MRPL37 are associated with higher risk of recurrent venous thromboembolism in a sex-specific manner
Recent studies indicate that mitochondrial DNA (mtDNA) dysfunction is a biomarker of oxidative stress and can predict the risk of cardiovascular diseases (CVDs). Genetic variants in PARK2 (rs4708928) and MRPL37 (...
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Article
Open AccessAssociation between TLR9 rs5743836 polymorphism and risk of recurrent venous thromboembolism
Recent gene knockout studies on mice have shown the role of toll-like receptor 9 (TLR9) in resolution of venous thromboembolism (VTE) through sterile inflammation. However, the role of a putative functional TLR9 ...
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Article
Thrombomodulin gene c.1418C>T polymorphism and risk of recurrent venous thromboembolism
Thrombomodulin gene (THBD) is a critical cofactor in protein C anticoagulant system. THBD c.1418C>T polymorphism is reported to be associated with higher risk of primary venous thromboembolism (VTE) but its ro...
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Article
Transforming growth factor (TGF)-β levels and unprovoked recurrent venous thromboembolism
Prediction of recurrence in patients with unprovoked venous thromboembolism (VTE) remains a challenge. Studies of atherosclerosis suggest a protective role of transforming growth factor (TGF)-β. However, the r...
