5 Result(s)
within
Asbjørn Holmgren
English
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Article
Open AccessBipolar patients display stoichiometric imbalance of gene expression in post-mortem brain samples
Bipolar disorder is a severe neuro-psychiatric condition where genome-wide association and sequencing studies have pointed to dysregulated gene expression as likely to be causal. We observed strong correlation...
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Article
Open AccessMap** the expression of an ANK3 isoform associated with bipolar disorder in the human brain
The gene ankyrin-3 (ANK3) has been consistently associated with bipolar disorder (BD) in several genome-wide association studies (GWAS). The exact molecular mechanisms underlying this genetic association remain u...
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Article
Open AccessExploring lithium’s transcriptional mechanisms of action in bipolar disorder: a multi-step study
Lithium has been the first-line treatment for bipolar disorder (BD) for more than six decades. Although the molecular effects of lithium have been studied extensively and gene expression changes are generally ...
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Article
Open AccessElevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder
Ankyrin-3 (ANK3) is one of the few genes that have been consistently identified as associated with bipolar disorder by multiple genome-wide association studies. However, the exact molecular basis of the associati...
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Article
Open AccessHaploinsufficiency of two histone modifier genes on 6p22.3, ATXN1 and JARID2, is associated with intellectual disability
Nineteen patients with deletions in chromosome 6p22-p24 have been published so far. The syndromic phenotype is varied, and includes intellectual disability, behavioural abnormalities, dysmorphic features and s...
