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    Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

    Aicardi-Goutieres syndrome is a genetically determined encephalopathy that is associated with an increased production of interferon alpha, which in turn is central to the pathogenesis of systemic lupus erythem...

    Gillian I Rice, Jacquelyn Bond, Aruna Asipu, Rebecca L Brunette in Nature Genetics (2009)