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  1. Article

    Open Access

    An analytic and systematic framework for estimating metabolic flux ratios from 13C tracer experiments

    Metabolic fluxes provide invaluable insight on the integrated response of a cell to environmental stimuli or genetic modifications. Current computational methods for estimating the metabolic fluxes from 13C isoto...

    Ari Rantanen, Juho Rousu, Paula Jouhten, Nicola Zamboni… in BMC Bioinformatics (2008)

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  2. No Access

    Chapter and Conference Paper

    A Computational Method for Reconstructing Gapless Metabolic Networks

    We propose a computational method for reconstructing metabolic networks. The method utilizes optimization techniques and graph traversal algorithms to discover a set of biochemical reactions that is most likel...

    Esa Pitkänen, Ari Rantanen, Juho Rousu… in Bioinformatics Research and Development (2008)

  3. No Access

    Chapter and Conference Paper

    A Method for Estimating Metabolic Fluxes from Incomplete Isotopomer Information

    Metabolic flux estimation—the problem of finding out the rates of reactions in metabolic pathways—is an important problem area in the study of metabolism.The most accurate technique for this task today is the ...

    Juho Rousu, Ari Rantanen, Hannu Maaheimo… in Computational Methods in Systems Biology (2003)